The Lipid Profile of the Skin Surface in Acne

The purpose of this study is to evaluate the differences in the skin lipid profile of patients with and without acne. Secondly, the goal is to learn more about what the effects of retinoinds (topical and systemic) are on the the skin lipid profile. We hypothesize that the skin lipid profile of subjects with acne will be lower in inflammatory lipids in comparison to subjects without acne.

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Key information

Conditions

Acne Acne Vulgaris Acneiform Eruptions Sebaceous Gland Diseases Skin Diseases Skin and Connective Tissue Diseases

Age range

12 year–30 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Dermatology Research Area, Davis, California, United States

About this study

Skin lipid profile will be conducted via sebutapes- adhesive tapes that painlessly absorbs sebum from the face. These tapes will be placed on the face for 1 hour. A photograph of the face will be taken during each study visit. A sebumeter will also be used to measure skin sebum secretion rate.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age 12 to 30 years
have been prescribed tretinoin OR isotretinoin

Exclusion criteria

those who have taken isotretinoin (systemic)
those who used tretinoin or other topical retinoid within two weeks of starting the study
those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome
those who are pregnant, prisoners, or cognitively impaired
those who do not fit the inclusion criteria

Treatment and study plan

Tretinoin or Adapalene

Drug

Subjects will apply a pea sized amount of topical retinoid cream once daily at night for 30 days. Subjects will return for a follow-up visit.

Other names: Retin A

isotretinoin

Drug

Subjects will take one pill once daily for 5 months. Subjects will return after 1 month and after 4-5 months of treatment for skin lipid profiling.

Other names: Accutane

Primary outcomes

Skin lipid profile of acne and healthy patients

Time frame: baseline visit

Compare the skin lipid profile of acne and healthy patients at baseline

Secondary outcomes

Skin lipid profile of acne patients after treatment

Time frame: at 1 month and 4-5 months of treatment

Patients in the topical retinoid group will have their lipids evaluated after 1 month of treatment. Patients in the systemic retinoid (isotretinoin) group will have their lipids evaluated after 1 and 4-5 months of treatment.

Sponsors and collaborators

Lead sponsor

University of California, Davis

Other

Registry information

Acronym: Acne

Important dates

Study start: 2013
Primary completion: 2015
Study completion: 2015
First posted: Jul 2, 2014
Registry last updated: May 30, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed