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NCT Number: NCT04047212

The Link Between Periodontitis, Smoking and Oral Cancer

Periodontitis is a widely prevalent disease worldwide that has serious public health consequences. Its prognosis includes tooth loss and edentulism, a condition that negatively affects chewing causing functional disability; and esthetics causing social impairment. Consequently, periodontitis may end up causing marked impairment of the quality of life of the affected patients, impairment of general health and increasing the dental care costs significantly.

Changes in the oral mucosa arise by primary products resulting from tissue breakdown due to gingivitis. It then triggers the host cells to produce proteinases that mediate loss of marginal periodontal ligaments, apical migration of the junctional epithelium and apical spread of bacterial biofilm.

Therefore, this research aims to identify the risk of smoking to both periodontitis and oral cancer, and the risk of periodontitis to oral cancer.

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Key information

Conditions

Chronic Periodontitis Chronic Disease Disease Attributes Head and Neck Neoplasms Mouth Diseases Mouth Neoplasms Neoplasms Neoplasms by Site Oral Cancer Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients 18 years or older.

Exclusion criteria

  • Patients with any systemic diseases.
  • Pregnant females.
  • Handicapped and mentally retarded patients.
  • Patients undergoing radiotherapy.
  • Patients having oral cancer

Treatment and study plan

biopsy for oral cancer

Diagnostic Test

surgical biopsy is to be taken for diagnosis of oral cancer or premalignant lesions

periodontal examination

Diagnostic Test

Periodontal clinical examination to all by periodontal charting

Primary outcomes

  1. Periodontitis

    Time frame: the 10 years of the study

    arising of periodontitis or increase in the grade of an already existing case of periodontitis

Secondary outcomes

  1. Oral cancer

    Time frame: the 10 years of the study

    Arising of a lesion of oral cancer or a premalignant lesion

Study contacts

Contact information is provided by the study sponsor or research team.

Ayat Gamal-AbdelNaser

CONTACT

[email protected]

01001874257

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Analysis of the Link Between Periodontitis, Smoking and Oral Cancer: Cohort Study

Important dates

Study start
2021
Primary completion
2031
Study completion
2032
First posted
Aug 6, 2019
Registry last updated
Jun 16, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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