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Completed

NCT Number: NCT04638205

The Life Paths That Lead Teenagers to Attempted Suicide:Trajectories of Proximal Adversity

Suicidal behaviors seriously alter the vital and functional prognosis of adolescents. Although the literature has lighted out a considerable number of risk factors for suicide attempts in youth, theoretical models - among which bio-psycho-social models - still lack empirical evidence. More specifically, the way adverse life events dynamically interact together and with the individual's diathesis to precipitate suicidal attempts remains unclear. Studies of life trajectories have opened an alternative approach to traditional linear epidemiological analysis to capture such a complex process. To date, adverse trajectories approaches never have been applied to the period immediately preceding the occurrence of the suicidal gesture (proximal adverse trajectories).

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Key information

Conditions

Suicide, Attempted Behavior Behavioral Symptoms Self-Injurious Behavior Suicide

Age range

15 year–24 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hop Fontan - Chu Lille

Lille, 59037, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Inclusion criteria for cases
  • Youth aged 15-24 inclusive
  • Who stayed at the hospital or in the emergency room for less than 15 days after a first suicide attempt
  • Who were discharged less than 15 days ago
  • Who gave their informed consent for majors, or whose parents gave their informed consent for minors Inclusion criteria for controls
  • Youth aged 15-24 inclusive
  • Who have never experienced any suicidal ideation or suicide attempt
  • Who gave their informed consent for majors, or whose parents gave their informed consent for minors Inclusion criteria for informants
  • Close relatives of the participant
  • Who are major
  • Who lived in the same household as the participant or have interacted with him/her for more than half the weeks of the year preceding the index suicide attempt

Exclusion criteria

  • No consent or consent withdrawal for majors and/or their parents for minors
  • Neurological or psychiatric condition altering the capacity to understand

Treatment and study plan

Primary outcomes

  1. Growth parameters of the patterns of proximal adverse trajectories in adolescents who attempted suicide, as compared to non-suicidal adolescents

    Time frame: 1 year

    We will build growth mixture models to account for the 1-year longitudinal evolution of the Burden of Adversity values. Each group will be characterized by the parameters (intercepts and slopes) of the best-fitting model.

    We will the compare the parameters of the 2 groups to search for statistical differences

Secondary outcomes

  1. Statistical tests comparing the sociodemographic, vulnerabily and psychopathological indicators between the sub-group of adolescents identified from the mixture model.

    Time frame: 1 year

    Growth mixture models will allow for identifying sub-groups of individuals who are similar as regards to their burden of adversity trajectories. We will compare the characteristics of theses subgroups

  2. Growth parameters of the patterns of evolution of psychological pain

    Time frame: 1 year

    Parallel to the burden of adversity growth models, we will build, for each group, growth models to predict the longitudinal evolution of psychological pain.

    We will then test whether the growth parameters of the ideation/pain trajectories correlate with those of the adversity trajectories

  3. Growth parameters of the patterns of evolution of suicidal ideation intensity

    Time frame: 1 year

    Parallel to the burden of adversity growth models, we will build, for each group, growth models to predict the longitudinal evolution of the severity of the suicidal ideations.

    We will then test whether the growth parameters of the ideation/pain trajectories correlate with those of the adversity trajectories

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Official study title

The Life Paths That Lead Teenagers to Attempted Suicide: Trajectories of Proximal Adversity

Acronym: TAPAS

Important dates

Study start
2019
Primary completion
2022
Study completion
2022
First posted
Nov 20, 2020
Registry last updated
Dec 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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