The Learning Registry

DCRI will utilize data on patients with ASCVD from the Cerner's health systems who have agreed to participate in the Learning Registry. Cerner will de-identify the data and place it into a cloud-based server hosted by Amazon Web Services that is password-protected and accessible only to DCRI researchers.

The research goals for the Learning Registry are,

• Evaluate treatment patterns and gaps in care for patients with atherosclerotic cardiovascular disease.

Across adults with ASCVD, treatment patterns for those groups will be evaluated, including aspirin, beta blockers, ace inhibitors, P2Y12 inhibitors, statins, and other antithrombotics. Factors associated with appropriate therapy use will be assessed, including patient level factors (age, race, sex, insurance status), clinical factors (type of ASCVD, comorbidities including kidney disease, atrial fibrillation, hypertension, diabetes, duration since last event), and system level factors (type of provider seen, frequency of contact with the healthcare system). Stratified analyses will include, but is not limited to, adults with PAD and adults who would have been eligible for the COMPASS trial.

• Estimate the attributable risk of modifiable risk factors on recurrent cardiovascular events in adults with established ASCVD.

Patients who present with myocardial infarction, unstable angina, stroke, and TIA will be identified. Those who have been previously seen in the outpatient setting will be evaluated for the presence of pre-existing cardiovascular disease to identify those with CVD prior to their event. Risk factor control prior to the event will be assessed. The amount of disease potentially preventable by risk factor control, as well as utilization of novel secondary preventive therapies including rivaroxaban will be evaluated.

Inclusion criteria

• Adults 18 and older For the overall ASCVD population, diagnose codes for cardiopulmonary disease, including disease of the pulmonary circulation, cardiac disease, and vascular disease will be used to identify the population to be de-identified. At MU, this will include patients back to 2012, and at Seton this will include patients back to 2014, which reflect dates of data availability at each health system. For both institutions, data collection for patients identified will stop at the end of 2019.

For the chart review population, patients with hospitalization for cerebrovascular disease (e.g. stroke/TIA), coronary heart disease (i.e. myocardial infarction), and peripheral vascular disease (e.g. limb ischemia) will be eligible.

Exclusion criteria

• none