The Involvement of the Gut Hormone GIP in the Pathophysiology of Post Prandial Hypotension

The study is an exploratory, randomised, placebo-controlled, double-blind crossover study comprising two experimental days with an infusion of the GIP receptor antagonist, GIP(3-30)NH2 (NH2 is the aminogroup), and placebo (saline) during a 180-minute mixed meal test (MMT). Eighteen participants, men and women, with MMT confirmed PPH will be included in the study.

Inclusion criteria

• Age 18-85 years
• History of PPH-related symptoms like dizziness, lightheadedness, palpitations, or fainting after meal ingestion
• Informed consent

Exclusion criteria

• Not fulfilling the PPH diagnosis during the mixed meal test or during the test meal with increased (+25%) number of calories
• Treatment with antihypertensives
• Treatment with SNRI (Serotonin and Noradrenalin Reuptake Inhibitor) or treatment within three months before screening visit
• Allergy or intolerance to ingredients included in the mixed meal
• Any ongoing medication that the investigator evaluates would interfere with trial participation
• Any physical or psychological condition that the investigator evaluates would interfere with trial participation, including any acute or chronic illnesses
• Anaemia (haemoglobin below normal range <7.3 mmol/L for women and <8.3 mmol/L for men)
• Moderate to severe loss of kidney function (estimated glomerular filtration rate (eGFR) <45 ml/min/1.73 m2) at screening
• Known liver disease (except for simple steatosis) and/or elevated plasma alanine aminotransferase (ALT) > three times the upper limit of normal at screening
• Any concomitant disease or treatment that, at the discretion of the investigators, might jeopardize the participant's safety during the trial
• Alcohol/drug abuse as per discretion of the investigators
• Pregnancy or breastfeeding
• Participation in any other clinical trial during study period
• Mental incapacity or language barriers that preclude adequate understanding or cooperation or unwillingness to comply with trial requirements or pr discretion of the investigator