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NCT Number: NCT06558487

The Internal Prospective Validation of the Cancer Admission Score (CAS) Prediction Model

The goal of this single center prospective observational study is to determine the agreement between the cancer admission score (CAS) predicted disposition and the actual disposition in patients with an active cancer diagnosis visiting the emergency department (ED). The main question it aims to answer are: Is the performance of the CAS good enough to play a potential role in the ED care process. For each participant the CAS will be calculated and compared to the actual outcome.

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Key information

Conditions

Oncology Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Erasmus University Medical Center

Rotterdam, South Holland, 3015GD, Netherlands

Location status: Recruiting

Location contact

Jason den Duijn, MSc.

CONTACT

[email protected]

+31107040704

About this study

The goal of this single center prospective observational study is to determine the agreement between the cancer admission score (CAS) predicted disposition and the actual disposition in patients with an active cancer diagnosis visiting the emergency department (ED). The main question it aims to answer are: Is the performance of the CAS good enough to play a potential role in the ED care process.

The first part of this study is an observational part. For patients with cancer that are presented to the emergency department (ED) the cancer admission score (CAS) will be calculated by the model both after triage and after the first blood results are in. Furthermore, the expected disposition will be asked to the attending nurse after triage and after the first blood results. Finally, the actual disposition will be written down after the patient has left the ED, in combination with ED length of stay (LOS) and the time for the attending physician to reach a decision about the disposition (time-to-disposition) and the time for a patient to leave the ED (time-to-leave).

The second part is the interventional part. In this part we introduce an early bed reservation intervention. The CAS is still calculated for the patient. If the CAS is 80% or higher based on the triage, the attending physician will be alerted and a call to the bed coordinator will be placed to reserve a bed in advance. After the first blood results are known the second CAS will be calculated, if this drops below 70% the reserved bed can be canceled by the attending physician. Similar to the first part, the expected disposition from the attending nurse after triage and after first blood results will be collected. Finally, the actual disposition, ED LOS, time-to-disposition and time-to-leave will be noted.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with solid or hematological malignancies and receiving systemic therapy or having received systemic therapy within the last 3 months.
  • Presented at or admitted from the emergency department for the oncology, hematology neuro- or lung-oncology clinical unit.

Exclusion criteria

  • <18 years old
  • Only received a surgical intervention as cancer treatment
  • Admitted to the ED for the surgical department

Treatment and study plan

Cancer Admission Score Prediction Model

Other

A prediction model that calculates the chance for a patient to be admitted after triage and after first blood results

Primary outcomes

  1. Cancer Admission Score

    Time frame: Through study completion, an average of 6 months

    Cancer Admission Score (CAS) calculated after triage and after first blood results, ranging from 0 to 100%. The higher the score the greater the change of admission

  2. Disposition

    Time frame: Through study completion, an average of 6 months

    The outcome of a visit to the ED, being either admission or home

  3. Agreement between the CAS and the actual disposition

    Time frame: Through study completion, an average of 6 months

    Agreement between the CAS predicted outcome and the actual outcome

Secondary outcomes

  1. Agreement between expected disposition by nurse and actual disposition

    Time frame: Through study completion, an average of 6 months

    Agreement between the nurse predicted outcome and the actual outcome

  2. time-to-disposition

    Time frame: Through study completion, an average of 6 months

    The average time between patient's arrival at the emergency department (ED) and the decision to disposition

  3. time-to-leave

    Time frame: Through study completion, an average of 6 months

    The average time between the decision to disposition and departure from the ED (either home or ward)

  4. ED Length of Stay

    Time frame: Through study completion, an average of 6 months

    The total time spent in the ED by a patient during their visit

Other outcomes

  1. Sex

    Time frame: Through study completion, an average of 6 months

    The sex of a patient

  2. Age

    Time frame: Through study completion, an average of 6 months

    The age of a patient

  3. Type of Cancer

    Time frame: Through study completion, an average of 6 months

    The type of cancer a patient has

  4. Type of Treatment

    Time frame: Through study completion, an average of 6 months

    Type of cancer treatment a patient receives

  5. Main Complaint

    Time frame: Through study completion, an average of 6 months

    Main complaint of ED visit

  6. Physical parameters recorded during triage

    Time frame: Through study completion, an average of 6 months

    Physical parameters that are recorded during triage and are used in the prediction model

  7. First Blood results

    Time frame: Through study completion, an average of 6 months

    The blood results that are recorded during triage and are used in the prediction model

Study contacts

Contact information is provided by the study sponsor or research team.

Jason den Duijn

CONTACT

[email protected]

0107040704

Sponsors and collaborators

Lead sponsor

Erasmus Medical Center

Other

Registry information

Official study title

The Internal Prospective validatiON of a prediCtiOn Model for the Change of admIssion for Patient With caNcer Admitted to the emerGency Department (ONCOMING Study)

Acronym: ONCOMING

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 16, 2024
Registry last updated
Aug 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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