The Innate Immune System and Inflammatory Bowel Disease

The study includes individuals with ulcerative colitis, Crohn's disease and healthy controls. The purpose of this study is to examine the innate immune system (IIS) by exposing peripheral blood monocytes to various ligands relevant for stimulation of the IIS and study the immune response. Colonic mucosal samples are examined to find gene expression patterns which may distinguish the two forms of disease from each other and from healthy controls.

The hypothesis is that the innate immune system has responses unique for the disease states, and that the diseases may be differentiated by examination of gene expression patterns in mucosal biopsies.

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Key information

Conditions

Ulcerative Colitis Colitis Colitis, Ulcerative Colonic Diseases Crohn Disease Crohn's Disease Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Inflammatory Bowel Diseases Intestinal Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Dept of Cancer Research and Molecular Medicine, NTNU

Trondheim, NO-7489, Norway

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Presence of ulcerative colitis
Presence of Crohn's disease
Healthy (no sign of inflammatory bowel disease)

Exclusion criteria

Anticoagulation
Cardiac valvular disease
Intravascular prosthesis
Coagulation disorders
Gastrointestinal malignancy

Treatment and study plan

Primary outcomes

gene expression patterns in mucosal biopsies

Time frame: 2 years

Sponsors and collaborators

Lead sponsor

Norwegian University of Science and Technology

Other

Collaborators

The Royal Norwegian Ministry of Health

Registry information

Important dates

Study start: 2007
Primary completion: 2017
Study completion: 2017
First posted: Aug 15, 2007
Registry last updated: Feb 14, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed