Skip to main content
OpenTrials
Completed

NCT Number: NCT01842412

The Initial Effect of Training on Mitochondrial Function in Patients With Intermittent Claudication

The hypothesis of this study is that one bout of leg exercise gives acute qualitative changes in mitochondrial function in claudication. Final purpose is to determine the optimal exercise frequency in treatment of claudication.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Intermittent Claudication Behavior Cardiovascular Diseases Motor Activity Pathological Conditions, Signs and Symptoms Peripheral Arterial Disease Peripheral Vascular Diseases Signs and Symptoms Vascular Diseases

Age range

50 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department for circulation and medical imaging, NTNU

Trondheim, Postboks 8905, 7491, Norway

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • A history of any type of uni- or bilateral exertion leg pain.
  • A maximal claudication distance that is less than 300 meter
  • Diagnosed with intermittent claudication secondary to vascular insufficiency
  • An ankle-brachial index between 0.4 and 0.9.
  • Lives in Trondheim

Exclusion criteria

  • Diagnosed with critical limb ischemia
  • ankle-brachial index > 0.90 or < 0.4
  • Limited exercise tolerance
  • Warfarin or heparin usage
  • Diabetes mellitus
  • Underwent a vascular intervention in the last 3 months
  • Active cancer, renal- or liver disease.

Treatment and study plan

Exercise

Behavioral

one bout of exercise training

Primary outcomes

  1. Mitochondrial function

    Time frame: One day

    respirometry

Sponsors and collaborators

Lead sponsor

Norwegian University of Science and Technology

Other

Collaborators

  • St. Olavs Hospital

Registry information

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Apr 29, 2013
Registry last updated
Oct 25, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.