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NCT Number: NCT05832307

The INFLUENTIAL Trial- Evaluation of National Inpatient Influenza Vaccination Program

This study plans to learn more about whether a stakeholder-informed, standardized inpatient vaccination program will increase influenza vaccination rates of hospitalized children across US pediatric health systems. The first part of the study is to form a multidisciplinary team of stakeholders, including parents, providers, nurses, pharmacists, informaticists, data analysts and communication experts across three sites in synthesizing a best practice implementation guide for an inpatient influenza vaccination program, which will then be piloted at these three sites.

Recruiting

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Key information

Age range

6 month–99 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ann and Robert Lurie's Children Hospital of Chicago, Chicago, Illinois, United States

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About this study

The overarching goal of this proposal is to determine whether a stakeholder-informed, standardized inpatient influenza vaccination program will increase influenza vaccination rates of hospitalized children across diverse U.S. pediatric health systems. Building upon preliminary data and experience with pediatric inpatient influenza vaccine delivery, the investigators will engage a multidisciplinary team of stakeholders in synthesizing a best practice implementation guide for an inpatient influenza vaccination program across three sites. The next phase of the study, using a novel adaptive trial design, will be to implement and test the program across 12 health systems. Finally, the investigators will evaluate the program's impact using an established dissemination and implementation framework.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • At least 6 months of age
  • Admitted to an inpatient unit at a participating health system

Exclusion:

  • Admission to critical care sites or hematology-oncology services

Exclusion criteria

  • At least 6 months of age
  • Admitted to an inpatient unit at a participating health system

Exclusion:

  • Admission to critical care sites or hematology-oncology services

Treatment and study plan

Existing Influenza Vaccination Practices

Other

Usual care is defined as the existing inpatient influenza vaccination practices that currently exist at a given site.

Standardized inpatient influenza vaccination program

Other

Intervention A: The basic intervention is the inpatient influenza vaccination program Intervention B: The intensified intervention is the multifaceted influenza vaccination strategy (Intervention A) plus a learning collaborative

Other names: Intervention A and B

Primary outcomes

  1. Vaccine administration rate

    Time frame: 1 year

    proportion of influenza vaccine administrations to eligible patients during hospitalization.

Study contacts

Contact information is provided by the study sponsor or research team.

Suchitra Rao

CONTACT

[email protected]

7207772823

Sponsors and collaborators

Lead sponsor

University of Colorado, Denver

Other

Collaborators

  • Agency for Healthcare Research and Quality (AHRQ)
  • Seattle Children's Hospital

Registry information

Official study title

The INFLUENTIAL Trial - Inpatient FLU Vaccination Program Effectiveness: National Trial Implementing Best Practices and Learning Collaboratives

Acronym: Influential

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Apr 27, 2023
Registry last updated
Apr 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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