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Completed

NCT Number: NCT03806543

The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level

The aim of this study was to assess factors that may influence vancomycin trough level and the rate achieving the target trough level in critically ill patients.

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Key information

Conditions

Vancomycin

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

This retrospective observational study included adult patients treated with intravenous vancomycin in intensive care unit of Zhongda Hospital from January 2015 to December 2017. Vancomycin dose was based on international consensus and adjusted according to estimated glomerular filtration rate (eGFR) calculated by the Cockcroft-Gault equation. vancomycin trough level (VTL) was retained at steady state (after the third dose). Linear regression was performed to determine the correlation between factors prior to the first vancomycin dose and VTL. Distribution of VTL and percentage of patients achieving the target trough level (15-20mg/L) was observed in different renal function.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult ICU patients (age≥18 years) treated with intravenous vancomycin were included

Exclusion criteria

  • Chronic renal dysfunction and acute renal injury patients treated with Renal Replacement therapy
  • VTL was not retained at steady-state
  • Vancomycin treatment time≤48h
  • Vancomycin dose did not meet study definitions
  • Palliative care

Treatment and study plan

Vancomycin

Drug

adult patients treated with intravenous vancomycin in intensive care unit

Primary outcomes

  1. Rate of patients achieving the target vancomycin trough（15-20mg/L）

    Time frame: 3 years

    Vancomycin trough level was retained at steady state (after the third dose). If a patient has multiple measurements of vancomycin trough level, the first measurement is collected.Rate of patients achieving the target trough level (15-20mg/L) was observed.

Sponsors and collaborators

Lead sponsor

Southeast University, China

Other

Registry information

Official study title

The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level in Critically Ill Patients: A Retrospective Observational Study

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Jan 16, 2019
Registry last updated
Jan 16, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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