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Completed

NCT Number: NCT05781685

The Influence of Testosterone on Experimental Pain Perception

This trial examined how the administration of exogenous testosterone would influence pain tolerance and other endogenous steroids (i.e. estradiol and progesterone).

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Key information

Conditions

Acute Pain Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–25 year

Sex eligibility

Female

Study type

Interventional

Phase

Early Phase 1

Primary location

University of New Mexico

Albuquerque, New Mexico, 87131, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy college-aged females that are over the age of 18 and younger than 25 will be used for this study.

Exclusion criteria

  • The following criteria will exclude a participant from the study:
  • Anyone that has a tree nut allergy.
  • Women that are pregnant or may feel that they may be pregnant or breast-feeding.
  • Anyone taking supplements that may influence their testosterone level.
  • Anyone taking any kind of steroid that may increase their testosterone level.
  • Anyone that smokes tobacco or uses smokeless tobacco.
  • Anyone that reports any condition associated with nerve damage.
  • Anyone that is using hormonal contraceptive.
  • Anyone who was sick or unwell at the time of screening.
  • Each participant completed a Testosterone Pre-Screen form. This form asked each participant individually whether they are taking any drugs or have any conditions that might be exacerbated by testosterone. This form was completed before they signed the consent form and each time they arrived in the lab for an experimental session.

Treatment and study plan

Testosterone

Drug

Sublingual testosterone was administered to participants. Participants would self-administer the testosterone to themselves.

Placebo Syrup

Other

Oil-based sublingual product.

Primary outcomes

  1. Pain Tolerance

    Time frame: 4 hours After Administration

    The ischemic discomfort task applied a sphygmomanometer (blood pressure cuff) 5 cm below their elbow. The cuff was inflated to 200 mmHg. Pain tolerance was measured by how long they could tolerate the ischemic discomfort task. However, task was only allowed to last for 6 minutes

Secondary outcomes

  1. Changes Testosterone Levels

    Time frame: Prior to Intervention (Baseline), 15 minutes Post Intervention

    The measured testosterone levels in the participants before and after receiving the intervention

  2. Changes Estradiol Levels

    Time frame: Prior to Intervention (Baseline), 15 minutes Post Intervention

    The measured estradiol levels in the participants before and after receiving the intervention.

  3. Changes Progesterone Levels

    Time frame: Prior to Intervention (Baseline), 15 minutes Post Intervention

    he measured progesterone levels in the participants before and after receiving the intervention.

Sponsors and collaborators

Lead sponsor

University of New Mexico

Other

Collaborators

  • American Psychological Association (APA)

Registry information

Official study title

The Influence of Testosterone on Experimental Pain Perception and Social Psychological Functioning

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Mar 23, 2023
Registry last updated
Aug 5, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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