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NCT Number: NCT06849076

The Influence of Talocrural Manipulation on Proprioception in Stroke

The aim of the study is to investigate the effect of talocrural joint manipulation on the ankle proprioception of patients with stroke.

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Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Vascular Diseases

Age range

45 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Bolu İzzet Baysal Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi

Bolu, Merkez, 14280, Turkey (Türkiye)

Location status: Recruiting

Location contact

adnan demirel, Assoc. Prof.

CONTACT

[email protected]

5334170651 ext. +90

burak mavuş, M.Sc.

CONTACT

[email protected]

5388178351 ext. +90

About this study

The study, utilizing a randomized crossover design, is planned to be conducted on a minimum of 26 patients with stroke who meet the inclusion and exclusion criteria. Patients included in the study will be randomly assigned to receive both placebo talocrural joint manipulation and talocrural joint manipulation interventions.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Two months or longer elapsed since the stroke,
  • A Mini-Mental State Examination score of 24 or higher,
  • Being between 45 and 75 years of age,
  • Having a Brunnstrom stage of 4 or above

Exclusion criteria

  • The presence of severe osteoarthritis in the lower extremity,
  • The presence of cancer or diabetic neuropathy,
  • The presence of vestibular disorder,
  • The presence of lower extremity ulceration or amputation,
  • Hemodynamic instability,
  • The presence of other neurological disorders (such as multiple sclerosis, Parkinson's disease),
  • Having experienced an acute lower extremity injury in the last six weeks,
  • History of lower extremity surgery
  • Lack of available range of motion values required for the ankle proprioception test

Treatment and study plan

Placebo Talocrural Joint Manipulation

Other

This intervention is a classic method used to evaluate the effect of talocrural joint manipulation.

Talocrural Joint Manipulation

Other

This technique, aiming to increase ankle dorsiflexion and mechanoreceptor activation, is based on the application of high velocity low amplitude traction to the joint.

Primary outcomes

  1. Ankle Proprioception

    Time frame: Change from baseline ankle proprioception immediately after the intervention

    The effect of talocrural joint manipulation on ankle proprioception will be evaluated using the Cybex isokinetic dynamometer. The device will analyze the passive joint position sense of the ankle in various positions.

Secondary outcomes

  1. Ankle Dorsiflexion Measurement

    Time frame: Change from baseline ankle dorsiflexion immediately after the intervention

    For the measurement of dorsiflexion range of motion, patients will be asked to stand facing a wall with the assessed leg positioned at the back. They will place their hands on the wall at shoulder width. While keeping the back knee in at least 20 degrees of flexion and ensuring the foot remains in contact with the ground, they will be instructed to lean forward as far as possible. The dorsiflexion range of motion will then be measured using a spirit level application on an iPhone placed one centimeter above the calcaneal tuberosity.

Study contacts

Contact information is provided by the study sponsor or research team.

burak mavuş, M.Sc.

CONTACT

[email protected]

5388178351 ext. +90

ömer dursun, Asst. Prof.

CONTACT

[email protected]

5426088687 ext. +90

Sponsors and collaborators

Lead sponsor

Bitlis Eren University

Other

Registry information

Official study title

The Effect of Talocrural Joint Manipulation on Ankle Proprioception in Post-Stroke Patients

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Feb 27, 2025
Registry last updated
Jul 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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