Skip to main content
OpenTrials
Completed

NCT Number: NCT05028491

The Influence of Meibomian Gland Expression on Corneal Aberrations in MGD Patients

To evaluate the influence of corneal-aberrations before and after the meibomian gland thermal massage treatment.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Meibomian Gland Dysfunction Eye Diseases Eyelid Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Eye Hospital of Wenzhou Medical College

Wenzhou, Zhejiang, 325027, China

About this study

62 MGD patients treated with meibomian gland thermal massage once a week for 3 to 4 weeks were recruited.The Ocular Surface Disease Index questionnaire; tear film assessment encompassing tear meniscus height and non-invasive keratograph breakup time ; meibography score,corneal fluorescein staining; the Schirmer I test ; expressible meibomian gland, and quality ,anterior and total corneal aberrations were evaluated before and after treatment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • tear break-up time (BUT) ≤10 seconds or Schirmer I test (SIT) ≤10 mm, the presence of dry eye symptoms, and fluorescein staining (FL) score <3 points and at least one lid margin abnormality and poor meibomian gland expressibility

Exclusion criteria

  • eyelid structure abnormal(Entropion , ectropion);
  • having received any other treatment for MGD within three months
  • history of ocular surgery
  • contact lens use
  • ocular infection
  • any type of corneal scarring

Treatment and study plan

Primary outcomes

  1. corneal aberration corneal aberrations

    Time frame: baseline and 1 week after treatment

    Corneal aberrations were measured with a Pentacam。 The anterior corneal wavefront aberration was expanded with normalized Zernike polynomials.The corneal aberration from 3rd to 6th order were recorded as the root mean square (RMS) for analysis.

Sponsors and collaborators

Lead sponsor

Wenzhou Medical University

Other

Registry information

Official study title

The Effect of Meibomian Gland Thermal Massage on Corneal Aberrations in Meibomian Gland Dysfunction Patients

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Aug 31, 2021
Registry last updated
Sep 8, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.