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OpenTrials
Completed

NCT Number: NCT06822699

The Influence of Leg Elevation on Noradrenaline Requirements During Cesarean Delivery

Spinal anesthesia is a widely chosen technique in obstetric theaters due to several advantages, however sympathetic block results in hypotension that carry several consequences on maternal and fetal health, thus early prediction and management takes high priority. in this regards recent recommendations suggest the use of prophylactic vasopressors like noradrenaline, researchers of this study aimed to explore the impact of leg elevation on prophylactic noradrenaline dose

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Key information

Conditions

Spinal Hypotension Hypoperfusion

Age range

20 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Cairo University

Cairo, Giza Governorate, 6890, Egypt

About this study

after spinal anesthesia, patients will be randomly allocated into 2 groups : Leg elevation group and control group.

noradrenaline will be used as variable infusion starting from 0.05 microgram/kg/min up to 0.14 microgram /kg/minute.

noradrenaline infusion will be continued till delivery of the baby

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • full term
  • singleton pregnancy
  • ASA II

Exclusion criteria

  • decline to participate
  • baseline SBP <100 mmHg
  • failed spinal anesthesia
  • allergy to local anesthetic
  • coagulopathy

Treatment and study plan

Leg elevation

Device

leg will be raised 30 degrees after spinal anesthesia using standardized pillow

Primary outcomes

  1. Average noradrenaline requirements

    Time frame: baseline to delivery of the baby

    average noradrenaline requirements in both groups (mcg/kg/min)

Secondary outcomes

  1. Total noradrenaline requirements

    Time frame: baseline to delivery

  2. incidence of spinal hypotension

    Time frame: baseline to delivery

  3. incidence of severe hypotension

    Time frame: baseline to delivery

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

The Influence of Thirty-degree Leg Elevation on Noradrenaline Requirements Administered as a Prophylactic Variable Infusion During Cesarean Delivery: An Open Label Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Feb 12, 2025
Registry last updated
May 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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