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Completed

NCT Number: NCT02007460

The Influence of High Impact Exercise on Musculoskeletal Health in Older Men

Osteoporotic fractures are an extremely common and serious public health issue which contribute substantially to pain, impaired mobility and morbidity in the elderly. Declines in bone strength combined with an increase risk of falls (associated with decline in muscular function with age) are the main determinants of fracture risk. Exercise that is novel and involves impact loading has the potential to improve bone strength and neuromuscular function (strength, power and balance). It is thus imperative to evaluate potential benefits of exercise in older people. The musculoskeletal responses to exercise may also be influenced by vitamin D status. It is the purpose of this study to consider the influence of a one year unilateral (one limb) high impact exercise programme on musculoskeletal health, specifically bone structure, muscle strength and power in older caucasian men. It is also the purpose of this study to determine whether this differs according to vitamin D status. The findings will reveal whether exercise can improve bone health and/or neuromuscular function, and whether improvements are dependent upon vitamin D status.

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Key information

Conditions

Bone Strength Neuromuscular Function

Age range

65 year–80 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Loughborough University

Loughborough, Leicestershire, LE11 3TU, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy community dwelling men of white european origin

Exclusion criteria

  • BMI >30 kg/m2
  • History of strength training or recently ( previous 12 months) doing moderate physical activity (weight bearing, high impact)
  • Recent ( previous 12 months) or current medical or surgical problems likely to affect bone metabolism or provide contraindications to high impact exercise, balance or neuromuscular function
  • Any previous or existing lower back or limb problems that could be exacerbated by undertaking high impact exercise
  • Any history of diagnosed or symptomatic diseases likely to influence strength, power, bone or habitual activity (including osteomalacia or impaired liver/renal function and locomotor disease, hypertension) that influences bone or muscle or precludes exercise

Treatment and study plan

Exercise

Behavioral

multidirectional unilateral hopping exercise

Primary outcomes

  1. Change in femoral neck bone mineral density

    Time frame: baseline, 12 months

Secondary outcomes

  1. Change in cortical bone mineral content

    Time frame: baseline, 12 months

  2. Change in trabecular bone mineral content

    Time frame: baseline, 12 months

  3. Change in ground reaction force during hopping

    Time frame: baseline, 6 months, 12 months

  4. Change in electromyography of quadriceps during hopping

    Time frame: baseline, 6 months

  5. Change in postural sway amplitude (mm)

    Time frame: baseline, 6 months

  6. Change in leg press strength

    Time frame: baseline, 6 months

  7. Change in maximal isometric knee extensor strength

    Time frame: baseline, 6 months

  8. Change in tendon stiffness

    Time frame: baseline, 6 months

Other outcomes

  1. Serum 25 hydroxy vitamin D

    Time frame: baseline

  2. Change in body fat content

    Time frame: baseline, 12 months

  3. change in energy intake (MJ/d)

    Time frame: baseline, 12 months

  4. change in calcium intake

    Time frame: baseline, 12 months

Sponsors and collaborators

Lead sponsor

Loughborough University

Other

Collaborators

  • University Hospitals of Derby and Burton NHS Foundation Trust
  • University Hospitals, Leicester

Registry information

Acronym: Hiphop

Important dates

Study start
2010
Primary completion
2012
Study completion
2012
First posted
Dec 10, 2013
Registry last updated
Dec 10, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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