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Completed

NCT Number: NCT02172677

The Influence of Collective Schemas on Individual Memory (MULTIBRAIN_1)

Schemas describe mental structures storing recurrent and organized pattern of information. Schemas may have a strong influence on the process of storing and retrieving new information into memory. Previous approaches in the cognitive neuroscience of memory have entirely focused on the individual dimension of preexisting schemas. In the real world though, much of our experiences and knowledge are collective or shared. Such social-cultural frameworks stored in collective memory may also reshape and reconfigure the construction of individual memories. Attempting to ascertain the influence of collective schema on the neural substrates of individual memories using cutting-edge brain imaging methods represents the challenge that MULTIBRAIN seeks to tackle. To achieve this goal, we will record brain activity in a group of 24 participants while there are remembering pictures from a tour at the World War II Memorial of Caen. This study will seek to identify brain areas of the prefrontal cortex encoding the organization of knowledge in collective memory using multivariate analyses of brain patterns of activation, and then to understand how such regions might modulate the recruitment of the hippocampus during episodic memory retrieval using analyses of effective connectivity. The organization of knowledge in collective memory is measured in parallel through 1) the analysis of French social memory of World War II using a corpus of 100 000 television and radio shows from the National Institute of Audiovisual, and 2) an internet task measuring the organization of individual knowledge in a large group of individuals that will allow to separate shared from non-shared memories of the World War II. Once collected, these data will help us to understand how collective schemas may reconfigure the organization of individual memories.

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Key information

Conditions

Episodic Memory

Age range

20 year–38 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

GIP Cyceron

Caen, 14074, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy participants between 20 and 38 years old
  • Affiliated to the French national health care system
  • French native speaker
  • Participated in a tour trip at the Memorial of Caen within the last 3 months
  • Right-handed
  • At least 2 years of education after graduating from high school
  • Body mass < 30kg/m2
  • Signed written consent form

Exclusion criteria

  • Pregnancy or intent to get pregnant
  • Person deprived of their liberty
  • Person hospitalized without consent
  • Minor
  • Protected adults or people unable to give informed consent
  • Person subjected to an exclusion period related to another protocol
  • History of neurological or psychiatric disorders or existence of traumatic brain injury with loss of consciousness for more than one hour
  • History of cancer with the last 5 years, excluding squamous cell carcinomas
  • Alcoholism, antecedents of chronic alcoholism or drugs abuse
  • Severe psychiatric disorders (according to DSM V diagnostic criteria) or psychological troubles which could affect participant's judgment
  • Use of medication that may interfere with cognitive or cerebral functioning
  • Presence of visual or hearing troubles that may compromise participant's ability to participate in the study
  • MRI Contraindications

Treatment and study plan

Episodic memory task

Behavioral

fMRI

Device

Primary outcomes

  1. Blood Oxigen Level Dependent (BOLD) response as measured with fMRI

    Time frame: 1 hour

Secondary outcomes

  1. Episodic memory performances - % of accuracy

    Time frame: 1 hour

Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Collaborators

  • Ecole Pratique des Hautes Etudes
  • Equipement d'Excellence Matrice
  • La Région Basse-Normandie
  • University Hospital, Caen
  • Université de Caen Normandie

Registry information

Official study title

ETUDE D'IMAGERIE PAR RESONANCE MAGNETIQUE FONCTIONNELLE CHEZ LE SUJET SAIN DES RELATIONS ENTRE MEMOIRE COLLECTIVE ET INDIVIDUELLE

Acronym: MULTIBRAIN_1

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Jun 24, 2014
Registry last updated
Sep 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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