Genetics of Beta Cell Failure in Mexican Americans
NCT03301519
Adipokines, Air Pollution
View Trial DetailsNCT Number: NCT07523659
Physical activity (PA) refers to bodily movements that result in a significant increase in energy expenditure due to the contraction of skeletal muscles. Physical inactivity has become a major global public health concern and is currently the fourth leading cause of death worldwide. The World Health Organization (WHO) recommends that adults engage in at least 150 minutes of moderate-intensity physical activity (MPA) or 75 minutes of vigorous-intensity physical activity (VPA) per week.
Although some studies suggest that individual differences in PA may have a genetic basis, PA is generally considered to be largely under voluntary control and influenced by climatic and environmental factors. For instance, extreme temperatures-either hot or cold-can increase health risks and reduce individuals' willingness to engage in physical activity. In addition, air pollution, particularly fine particulate matter (PM2.5), poses serious health risks. Exercising in polluted environments may trigger asthma, cardiovascular, or pulmonary conditions.
Since the Industrial Revolution, fossil fuel emissions have contributed to a global surface temperature increase of approximately 1.1°C, with projections suggesting a further rise of 2.5-2.9°C by the end of the century. At the same time, PM2.5 pollution has become a pressing issue, contributing to an estimated 7 million deaths globally in 2012-over one-third of which occurred in rapidly developing Asian countries.
Given the seasonal and geographic variability in climate and air quality, physical activity levels are likely to be affected accordingly.This study aims to investigate the extent to which climatic and environmental factors influence physical activity levels and intensity.
Interested in participating?
Request Info18 year–55 year
All sexes
Observational
Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, Shenzhen, Guangdong, China
This study will be conducted in two cities in China: Shenyang (41.481175°N) and Shenzhen (22.324386°N), with 62 participants recruited from each location. By assessing participants' body composition and physical activity levels, along with the climatic and environmental conditions in both cities, we aim to compare how different climates and environmental exposures influence physical activity.
Participants will be asked to wear a GT3X accelerometer every two months to monitor physical activity levels, and an iButton temperature sensor to record ambient temperature. A total of six measurement rounds will be conducted. Concurrently, atmospheric temperature data will be collected via local weather stations, and PM2.5 data will be obtained from publicly available sources.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Time frame: Through study completion, every two months across 6 assessment rounds, up to 12 months per participant
Physical activity in vector magnitude counts will be recorded using GT3X accelerometer worn near the hip for a consecutive period of 7 days. The monitor should not be worn while bathing or swimming.
Time frame: Through study completion, an average of 2 years
Temperature in degrees Celsius will be collected using the HOBO mini-weather station.
Time frame: Through study completion, an average of 2 years
Humidity in %RH will be collected using the HOBO mini-weather station.
Time frame: Through study completion, every two months across 6 assessment rounds, up to 12 months per participant
Exposure temperature in degrees Celsius will be measured by Ibutton. The Ibutton (DS1921G) monitors will be provided for the assessment of both indoor and outdoor temperature of their living environment. The iButtons be affixed to the hand bag to measure the subject exposure temperature.
Time frame: Through study completion, an average of 2 years
PM2.5 in μg/m3 will be collected through open data website.
Time frame: Through study completion, an average of 2 years
Sunshine duration in hours will be collected through open data website.
Time frame: Through study completion, every two months across 6 assessment rounds, up to 12 months per participant
Height in centimeters will be measured by Leicester stadiometer (Seca 217, Germany) to the nearest 0.1cm. Subjects wearing no shoes.
Time frame: Through study completion, every two months across 6 assessment rounds, up to 12 months per participant
Subjects will be asked to fast overnight and weight in kilograms will be measured using a calibrated Seca body weight scale first thing in the morning on subjects wearing light clothes and no shoes.
Time frame: Through study completion, every two months across 6 assessment rounds, up to 12 months per participant
Fat percentage in percentage will be measured using Bioimpedance Analysis (Tanita, MC-980).
Time frame: Through study completion, every two months across 6 assessment rounds, up to 12 months per participant
Fat mass in kilograms will be measured using Bioimpedance Analysis (Tanita, MC-980).
Time frame: Through study completion, every two months across 6 assessment rounds, up to 12 months per participant
Fat-free mass in kilograms will be measured using Bioimpedance Analysis (Tanita, MC-980).
Time frame: Through study completion, every two months across 6 assessment rounds, up to 12 months per participant
Muscle mass in kilograms will be measured using Bioimpedance Analysis (Tanita, MC-980).
Contact information is provided by the study sponsor or research team.
John R Speakman, Doctor
CONTACT
Xueying Zhang, Doctor
CONTACT
Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Other
The Influence of Climate and Air Pollution on Physical Activity of Chinese People in Shenyang(41.481175ºN) and Shenzhen(22.324386ºN)
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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