The Influence of Cancer Stem-cells on Risk of Relapse in Patients Harboring Adenocarcinoma and Squamous Cell Carcinoma of the Lung

The present study is a prospective cohort study. The aim is to assess the relationship between the presence of cancer stem-cells (CSC) and the risk of relapse in patients with early and locally advanced adenocarcinoma and squamous cell carcinoma of the lung

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Key information

Conditions

Lung Cancer, Nonsmall Cell Bronchial Neoplasms CSC Carcinoma, Bronchogenic Carcinoma, Non-Small-Cell Lung Disease Attributes Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Recurrence Relapse/Recurrence Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Azienda Ospedaliero-Universitaria di Modena

Modena, 41124, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with stage I, II or IIIA adenocarcinoma of squamous cell carcinoma of the lung
age between 18 and 85
R0 resection
availability of formalin-fixed, paraffin-embedded surgery specimen from the primary tumor
availability of fresh surgical specimen for cytofluorimetric analysis

Exclusion criteria

incomplete resection
unknown tumor, node or metastasis status
synchronous tumors
previous lung cancer

Treatment and study plan

Exposure to lung cancer stem cells

Genetic

The exposure to lung cancer stem cells was measure as the percentage of Aldehyde dehydrogenase (ALDH) on all viable cells extracted from surgically resected tumor specimens

Primary outcomes

Relapse Free Survival

Time frame: Minimum follow-up time: 1 year

Days from lung cancer resection to relapse

Sponsors and collaborators

Lead sponsor

Beatrice Aramini

Other

Registry information

Official study title

The Influence of Cancer Stem-cells on Risk of Relapse in Patients Harboring Adenocarcinoma and Squamous Cell Carcinoma of the Lung: a Prospective Cohort Study

Important dates

Study start: 2017
Primary completion: 2020
Study completion: 2020
First posted: Nov 18, 2020
Registry last updated: Jun 1, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed