The Incretin Effect in Patients With Chronic Pancreatitis

The phenomenon that oral glucose elicits a higher insulin response than does intravenous (iv) glucose, even at identical plasma glucose (PG) profiles (isoglycemia), is called the incretin effect. In type 2 diabetes mellitus (T2DM) the incretin effect has been shown to be markedly reduced or even abolished. It is not known whether the reduced incretin effect in T2DM is a primary event leading to T2DM or if it is merely a consequence of the diabetic state. To answer this question the investigators plan to estimate the incretin effect in 8 patients with secondary diabetes mellitus (DM) to chronic pancreatitis (CP) and compare it to the incretin effect of 8 patients with CP and normal glucose tolerance (NGT). Eight patients with T2DM and 8 healthy control subjects are studied for comparison. The incretin effect is measured by a 50-g oral glucose tolerance test and an isoglycemic intravenous glucose infusion.

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Key information

Conditions

Chronic Pancreatitis Chronic Disease Diabetes Mellitus Diabetes Mellitus, Type 2 Digestive System Diseases Disease Attributes Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases Pancreatic Diseases Pancreatitis Pancreatitis, Chronic Pathologic Processes Pathological Conditions, Signs and Symptoms Type 2 Diabetes Mellitus

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Gentofte University Hospital

Hellerup, Copenhagen County, 2900, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosis of chronic pancreatitis with secondary diabetes mellitus
Diagnosis of chronic pancreatitis with normal glucose tolerance
Diagnosis of type 2 diabetes
Normal level of hemoglobin
Normal level of se-creatinine

Exclusion criteria

GAD-65 autoantibodies
ICA autoantibodies
Albuminuria

Sponsors and collaborators

Lead sponsor

University Hospital, Gentofte, Copenhagen

Other

Collaborators

University of Copenhagen

Registry information

Official study title

The Incretin Effect in Patients With Chronic Pancreatitis With and Without Secondary Diabetes Mellitus

Important dates

Study start: 2006
Study completion: 2006
First posted: Mar 19, 2008
Registry last updated: Jan 13, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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