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Completed

NCT Number: NCT02152839

The Implementation of Novel 'Heavy' Water Techniques for Determining Modulation of Muscle Protein, DNA and Lipid Synthesis Due to Ageing

Maintenance of body's skeletal muscle is key to a healthy older age. However, as we age we lose on average 1-2% of our muscle each year. In order to slow this loss we need to understand fully the mechanisms regulating muscle mass with ageing. In this project we aim to determine these mechanisms using a new novel technique of 'heavy' water ingestion, which will allow us to measure multiple aspects of skeletal muscle mass control during normal everyday activities in young and old individuals over a period of 6 weeks. We will also determine the influence of resistance exercise training during this period in offsetting declines in muscle with ageing using this method

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Key information

Conditions

Healthy

Age range

18 year–75 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Royal Derby Hospital Medical School

Derby, DE22 3DT, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Young (18-30y) and old men (65-75y) who are generally healthy and recreationally active

Exclusion criteria

  • Active cardiovascular disease
  • Cerebrovascular disease including previous stroke, aneurysm (large vessel or intracranial)
  • Respiratory disease including pulmonary hypertension or COPD
  • Hyper/ hypo parathyroidism, hyper/ hypothyroidism, Cushing's disease, diabetes
  • Active inflammatory bowel disease
  • Renal disease
  • Malignancy
  • Recent steroid treatment (within 6 mo), or hormone replacement therapy
  • Clotting dysfunction
  • Musculoskeletal or neurological disorders
  • Any disease requiring long-term drug prescriptions, including statins

Treatment and study plan

Resistance exercise

Behavioral

6 Weeks progressive unilateral resistance exercise, 3 times per week, 70% 1-RM, 6 x 8 Repetitions. 2 minutes rest between sets

Primary outcomes

  1. Muscle Protein Synthesis

    Time frame: 0-6 Weeks

    Comparison of muscle protein synthesis between young and older individuals and in response to 6 weeks unilateral exercise training

Secondary outcomes

  1. Muscle Sub fractions

    Time frame: 0-6 week

    Comparison of different sub fractions involved in muscle mass regulation between young and older individuals and in response unilateral exercise training

Other outcomes

  1. Muscle Functions

    Time frame: 0-6 Weeks

    Muscle Strength and power un young and older individuals in response to unilateral exercise training

Sponsors and collaborators

Lead sponsor

University of Nottingham

Other

Collaborators

  • Physiological Society

Registry information

Important dates

Study start
2013
Primary completion
2014
First posted
Jun 2, 2014
Registry last updated
Jul 31, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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