The Implementation of Genetic Risk for Colorectal Cancer Screening

The goal of this study is to investigate genetic risk for colorectal cancer utilizing polygenic risk scores (PRS) for adults over 45 who have not received their first colonoscopy. The main questions it hopes to address are:

1. How does knowledge of a patient's genetic risk for colorectal cancer affect the uptake of initial screening colonoscopies? 2. How do colonoscopy outcomes compare between genetic risk groups?

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Key information

Conditions

Colorectal Cancer Colonic Diseases Colorectal Adenoma Colorectal Neoplasms Colorectal Polyp Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Rectal Diseases

Age range

45 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Endeavor Health

Evanston, Illinois, 60201, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Due for initial screening colonoscopy per current guidelines

Exclusion criteria

Prior colonoscopy
Prior personal history of colorectal cancer or inflammatory bowel disease
Medical contraindications to colonoscopy/sedation

Treatment and study plan

Primary outcomes

Number of scheduled colonoscopies in each genetic risk group

Time frame: One year following enrollment

Secondary outcomes

Number of polyps and/or adenomas found through colonoscopy in each genetic risk group

Time frame: One year following enrollment

Sponsors and collaborators

Lead sponsor

Endeavor Health

Other

Registry information

Official study title

Prospective Trial for the Implementation of Genetic Risk for Colorectal Cancer Screening

Acronym: PRO-GENE-COLON

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2027
First posted: Jun 2, 2026
Registry last updated: Jun 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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