Completed

NCT Number: NCT06095609

The Implementation of Early Mobilization and Chest Physiotherapy on Weaning Rate of Prolong Weaning Patients.

Weaning from mechanical ventilator is essential to liberate patients to normal life. Prolong weaning is defined as failure of 3 times spontaneous breath trial (SBT) and requiring more than 7 days weaning from mechanical ventilation after first SBT. higher unsuccessful rate of extubation and higher mortality rate. Possible reasons to cause prolong weaning could be attributed to intensive care unit acquired weakness (ICU-AW) and poor lung hygiene. In order to solve these two problems and increase the weaning rate, early mobilization (EM) and chest physiotherapy (CPT) are considered as possible strategy to attain the goal. According to previous articles, lacking of control group and small sample size made it difficult to confirm the true effect of EM and CPT on prolong weaning patients. Thus, the aims of this articles are discussing the influence from EM with CPT on weaning rate and other hospitalization outcomes with larger sample sizes and control group.

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Key information

Conditions

Prolonged Weaning, Early Mobilization, Chest Physiotherapy

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Taoyaun General Hospital, Ministry of Wealth and Health

Taoyuan, Taoyuan Dist., 330, Taiwan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

The subjects' data which met the inclusion criteria are: 1. Age>20 2. Patient with or without 3. Patient who met the criteria of received physiotherapy (Figure 1.) 4. No usage of life support device such as ECMO and so on. 5. Continuous mechanical ventilator use over 21 days.

Exclusion criteria

The exclusion criteria are 1. Patients diagnosed as brain death 2. Patients who were ventilator dependent before admission 3. Patients who were against advice discharge under critical condition. 4. Patients received emergency intervention during course. 5. Patient who didn't meet the criteria of received physiotherapy (Figure 1.).

Treatment and study plan

Early mobilization plus chest physiotherapy

Other

Early mobilization:early mobilization has been confirmed its positive effectiveness on cutting down the MV use days and mortality rate, attenuating the side effect such as muscle strength loss and functional activity dysfunction resulting from ICU acquired weakness among the patients with mechanical ventilation.

Chest physiotherapy:a common technique to reduce the respiratory complications in ICU, has been proved certain positive influence on airway clearance and hospital lengths of stay.

Primary outcomes

Weaning success rate

Time frame: up to 6 weeks in respiratory care center

Weaning success was defined as patients being free from MV or BiPAP for 5 days based on Taiwan

Secondary outcomes

RCC mortality rate

Time frame: up to 6 weeks in respiratory care center

the mortality rate of respiratory care center
hospital mortality rate

Time frame: up to 6 weeks in respiratory care center

the mortality rate during the hospital course
discharge to home rate

Time frame: after 6 weeks in respiratory care center

The rate of going home after discharge
total mechanical ventilator use

Time frame: up to 6 weeks in respiratory care center

The days of mechanical use during the admission time
RCC days of stay

Time frame: up to 6 weeks in respiratory care center

The days staying in respiratory care center
total hospital days of stay

Time frame: up to 10 weeks in the hospital

The days staying in the hospital

Sponsors and collaborators

Lead sponsor

Taoyuan General Hospital

Other Gov

Registry information

Official study title

The Implementation of Early Mobilization and Chest Physiotherapy on Weaning Rate of Prolong Weaning Patients. A Retrospective Study

Important dates

Study start: 2022
Primary completion: 2022
Study completion: 2022
First posted: Oct 23, 2023
Registry last updated: Oct 23, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.