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NCT Number: NCT07628868

The Impact of Ultrasound Measurements in Predicting Difficult Airway on Videolaryngoscopy Success

In this preoperative observational study, the effect of preoperative ultrasonographic measurements on the success of videolaryngoscopy in predicting difficult airways was investigated; furthermore, the aim was to determine new cut-off values that can predict difficult intubation in videolaryngoscope use. In our study, it was tested that the use of videolaryngoscope significantly increased the success of intubation in patients who were assessed as having difficult airways with upper airway ultrasound measurements.

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This study is active but is not currently recruiting participants.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

SBÜ Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi

Istanbul, Bakirköy, 34147, Turkey (Türkiye)

About this study

Upper airway ultrasonography has emerged as a promising tool for difficult airway assessment by enabling non-invasive, bedside, repeatable, and objective evaluation of airway anatomy. However, a substantial proportion of the existing literature has correlated ultrasonographic measurements with direct laryngoscopy findings. Whether these measurements retain their predictive value in the setting of videolaryngoscopy, and which ultrasonographic parameters best reflect technical intubation difficulty during videolaryngoscopic intubation, remain unclear. Furthermore, several studies have proposed specific cut-off values for upper airway ultrasonographic measurements to predict difficult laryngoscopy when direct laryngoscopy is used. However, these cut-off values may not be directly applicable to videolaryngoscopy because the improved glottic visualization provided by videolaryngoscopes fundamentally alters the relationship between airway anatomy and intubation difficulty.

Therefore, after obtaining a detailed medical history, including both general medical and difficult airway-related history, all patients underwent a comprehensive airway assessment. Conventional predictors of difficult airway were evaluated, including Mallampati classification, inter-incisor distance, thyromental distance, atlanto-occipital joint extension, neck circumference, and the upper lip bite test.

On the day of surgery, ultrasonographic measurements including the distance from the skin to the epiglottis (ESD), hyomental distance (HMD), tongue thickness (TT), and tongue cross-sectional area (CSA) will be obtained. Following these assessments, patients will be transferred to the operating room, where standard general anesthesia induction will be performed. Orotracheal intubation will subsequently be carried out using a videolaryngoscope. After intubation, the difficulty of mask ventilation, laryngoscopy, and orotracheal intubation will be evaluated by the anesthesiologist using established clinical assessment tools and scoring systems.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18 years and older
  • Patients undergoing elective surgery under general anesthesia requiring endotracheal intubation (ASA I-III)

Exclusion criteria

  • Patients undergoing surgery under sedation or regional anesthesia
  • Patients not planned for endotracheal intubation
  • Patients with a history of difficult airway
  • Patients with an acute respiratory tract infection
  • Patients with congenital or acquired upper airway anomalies
  • Patients with facial or maxillofacial tumors or fractures
  • Patients with cervical spine fracture
  • Patients with a history of cervical or craniofacial radiotherapy
  • Patients with a tracheostomy
  • Pregnant patients
  • Patients who do not meet the required fasting period or who refuse to -participate in the study

Treatment and study plan

Primary outcomes

  1. Difficult videolaryngoscopic intubation

    Time frame: During videolaryngoscopy (periprocedural)

    Difficult videolaryngoscopic intubation will be assessed using the VIDIAC score, a scoring system specifically developed to quantify intubation difficulty during videolaryngoscopy.

Secondary outcomes

  1. Difficult mask ventilation

    Time frame: During ventilation (periprocedural)

    Difficult mask ventilation will be assessed after anesthesia induction and during ventilation.

Sponsors and collaborators

Lead sponsor

Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Other Gov

Registry information

Official study title

Impact of Airway Ultrasound Measurements on the Success of Videolaryngoscopy in Predicting Difficult Airway

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 5, 2026
Registry last updated
Jun 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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