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Completed

NCT Number: NCT02496455

The Impact of the SCN9A Gene Polymorphism on Postoperative Pain

The purpose of this study to determine the association between postoperative pain after cesarean section and several single nucleotide polymorphisms in SCN9A sodium channels gene.

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Key information

Conditions

Pain, Postoperative Neurologic Manifestations Pain Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Pregnancy Signs and Symptoms

Age range

18 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

Gaziosmanpasa University Medical School Hospital

Tokat Province, 60100, Turkey (Türkiye)

About this study

SCN9A gene encodes an alpha subunit of the voltage-gated sodium channel (Nav1.7) and polymorphisms of this gene are associated with severe pain disorders. The impact of the polymorphisms in SCN9A on postoperative pain and opioid consumption after cesarean section is unclear.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The women aged 18 to 45,
  • in 36 to 40 weeks of pregnancy
  • undergoing cesarean section

Exclusion criteria

  • History of chronic pain or pain disorders
  • Psychiatric diseases
  • Diabetes mellitus
  • Severe cardiovascular, kidney or liver diseases
  • Alcohol or drug abuse
  • Heavy smoker
  • Unable to use the Patient controlled analgesia (PCA) pump

Treatment and study plan

cesarean section

Procedure

Women in 36 to 40 weeks of pregnancy undergoing cesarean section by Pfannenstiel technique

Opioid Tramadol

Drug

Tramadol will be administered via patient controlled analgesia (PCA) pump in the postoperative period

Other names: Tramadol (contramal)

Primary outcomes

  1. Pain

    Time frame: up to postoperative 24 hours

    The pain will be evaluated with the visual analog scale

Secondary outcomes

  1. Opioid consumption

    Time frame: Up to postoperative 24 hours

    The total amount of the tramadol administered to the patient will be recorded

Sponsors and collaborators

Lead sponsor

Tokat Gaziosmanpasa University

Other

Registry information

Official study title

The Impact of the Single Nucleotide Polymorphisms rs6746030,rs7604448, rs10930214, s7595255 in SCN9A Gene on Postoperative Pain and Analgesic Consumption After Cesarean Section

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Jul 14, 2015
Registry last updated
Nov 21, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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