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OpenTrials
Completed

NCT Number: NCT02792140

The Impact of the Opiate Antagonist Naltrexone on the Emotional Valence of Dreams

In this study, the investigators pose the question which influence the opioid circuit has on positive valent situations in dreams.

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Key information

Conditions

Neuroscience of Dreaming, Healthy

Age range

20 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 4

Primary location

University of Bern

Bern, Canton of Bern, 3012, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Written informed consent
  • Healthiness
  • Good capacity of remembering dreams
  • No opiate consumption

Exclusion criteria

  • Simultaneous participation in other studies
  • Addictive disorder
  • Abnormal liver function
  • Abnormal kidney function
  • Hypersensitivity to active ingredient or pharmaceutical additives
  • Hereditary galactose intolerance
  • Lactase deficiency
  • Glucose-galactose malabsorption
  • Intake of opioid medication

Treatment and study plan

Naltrexone

Drug

one week

Other names: Naltrexin

Placebo

Other

one week

Other names: Placebo Pills

Primary outcomes

  1. VAS-difference concerning the emotional valence of dreams

    Time frame: 7 days per condition (Naltrexone, Placebo), intermitted by 14 days of washout

    Difference between the mean values of emotional valence of dreams reported in the conditions (Naltrexone, Placebo), as captured in VAS [visual analog scales] for every dream

Secondary outcomes

  1. Semiquantitative score of emotional valence of dreams

    Time frame: 7 days per condition (Baseline, Naltrexone, Placebo), intermitted by 14 days of washout

    Based on computational linguistic analysis of the dreams

  2. Qualitative score of emotional valence of dreams

    Time frame: 7 days per condition (Baseline, Naltrexone, Placebo), intermitted by 14 days of washout

    Based on lexical coding of the dreams

Sponsors and collaborators

Lead sponsor

University of Bern

Other

Collaborators

  • Insel Gruppe AG, University Hospital Bern

Registry information

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Jun 7, 2016
Registry last updated
Apr 5, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.