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Completed

NCT Number: NCT02344381

The Impact of Sucrose Ingestion Post-Exercise on Liver and Muscle Glycogen Repletion.

Carbohydrate is stored in the body as glycogen, which is mainly found in the liver and muscle. During endurance exercise, muscle glycogen is used as fuel for the working muscles and liver glycogen is broken down to provide glucose to maintain blood glucose (sugar) levels. Both liver and muscle glycogen are important for our ability to perform intense/prolonged endurance exercise. Therefore, it is important to replete these stores after an intense/prolonged endurance exercise session in order to recover and perform optimally during a subsequent exercise bout, especially if the next exercise session is within 24h (e.g. stage races such as the Tour de France, tournament-style competitions such as the Olympic games and ultra-endurance events).

Carbohydrate intake has been shown to increase the availability of glycogen in the muscle and liver after exercise. The carbohydrates typically found in sports drinks are glucose and sometimes fructose. It has been observed that the ingestion of glucose will lead to a maximum rate of absorption of approximately ~1 g/min. However, if we also provide a different source of carbohydrate (fructose) then this is absorbed through a different pathway and therefore we can absorb up to ~1.75 g/min of carbohydrate. In addition, both carbohydrate sources are metabolised differently in the human body. By supplementing both glucose and fructose, we can potentially replenish the liver and muscle glycogen stores at a faster rate than ingestion of glucose only.

Sucrose is a naturally occurring sugar that is made up of a single glucose and single fructose molecule. Therefore, theoretically, this can use the two different pathways of absorption and also maximise carbohydrate delivery. It is not yet known however, what impact this has on our liver and muscle glycogen stores post-exercise when supplemented in relatively high amounts. Therefore the aim of this study is to assess whether relative high amounts of sucrose ingestion will improve liver and muscle glycogen repletion after endurance exercise.

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Key information

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Northumbria University

Newcastle upon Tyne, North East, NE1 8ST, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • Endurance trained cyclists/triathletes
  • VO2 max ≥ 50 ml/kg/min

Exclusion criteria

  • Use of medication
  • Smoking
  • Metabolic disorders

Treatment and study plan

Sucrose

Dietary Supplement

Glucose

Dietary Supplement

Primary outcomes

  1. change in liver glycogen concentration

    Time frame: 5 h

    The change in liver glycogen content will be determined post-exercise using 13C magnetic resonance spectroscopy

Secondary outcomes

  1. Change in muscle glycogen concentration

    Time frame: 5 h

    The change in muscle glycogen content will be determined post-exercise using 13C magnetic resonance spectroscopy

  2. Plasma glucose concentration

    Time frame: 5 h

  3. Plasma insulin concentration

    Time frame: 5 h

  4. Plasma lactate concentration

    Time frame: 5 h

Sponsors and collaborators

Lead sponsor

Northumbria University

Other

Collaborators

  • Maastricht University
  • Newcastle University
  • Sugar Nutrition

Registry information

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Jan 26, 2015
Registry last updated
Oct 23, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.