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NCT Number: NCT05468255

The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults

The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.

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Key information

Conditions

Glucose Intolerance Behavior Exercise Glucose Metabolism Disorders Hyperglycemia Metabolic Diseases Motor Activity Nutritional and Metabolic Diseases Vascular Function

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Old Dominion University

Norfolk, Virginia, 23529, United States

Location status: Recruiting

Location contact

Leryn J Reynolds

CONTACT

[email protected]

757-683-4974

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 55 years and older, 18-40 years old
  • Healthy, physically active, performing at least 90 min/week of physical activity
  • Free of physical limitations that may interfere with alterations in daily physical activity levels

Exclusion criteria

  • Physician diagnosed HIV, hepatitis, or tuberculosis.
  • Body weight change of greater than 5% within the previous 2 months
  • Smoking within the previous 2 months.
  • Taking medications that alter blood glucose levels

Treatment and study plan

removal of exercise

Other

Subjects will stop doing their normal exercise routines for 3 or 5 days and then subjects will resume doing their normal exercise routines for 3 days.

Other names: return to exercise

Primary outcomes

  1. Continuous glucose monitoring

    Time frame: 3 days before removal of exercise

  2. Continuous glucose monitoring

    Time frame: After removal of exercise for 5 days

  3. Continuous glucose monitoring

    Time frame: After return to exercise for 3 days

  4. Flow mediated dilation

    Time frame: 3 days before removal of exercise

    This measure assess blood vessel health non-invasively

  5. Flow mediated dilation (vascular health)

    Time frame: After removal of exercise for 5 days

    This measure assess blood vessel health non-invasively

  6. Flow mediated dilation (vascular health)

    Time frame: After return to exercise for 3 days

    This measure assess blood vessel health non-invasively

Study contacts

Contact information is provided by the study sponsor or research team.

Leryn Reynolds

CONTACT

[email protected]

757-683-4974

Sponsors and collaborators

Lead sponsor

Old Dominion University

Other

Registry information

Official study title

The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
Jul 21, 2022
Registry last updated
Apr 10, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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