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Completed

NCT Number: NCT05170854

The Impact of Liver Cirrhosis on Outcomes in Trauma Patients

Given that there are only a few studies on the effects of cirrhosis on trauma patients and none have addressed the impact cirrhosis has on the incidence of infections, it is important that we study this to determine the mortality in cirrhotic trauma patients and ascertain the incidence of infectious complications in these patients. We hypothesize that trauma patients with cirrhosis will have higher rates of mortality and infectious complications.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Methodist Health System

Dallas, Texas, 75203, United States

About this study

There have been a select few studies addressing the effects of cirrhosis on trauma patients. These studies show an increase in morbidity and mortality. However, there is limitation in the depth and breadth of analysis. The primary aim of this study is to determine the mortality rates in cirrhotic trauma patients with a secondary end-point being the determination of the incidence of infections associated with these patients.

Given that there are only a few studies on the effects of cirrhosis on trauma patients and none have addressed the impact cirrhosis has on the incidence of infections, it is important that we study this to determine the mortality in cirrhotic trauma patients and ascertain the incidence of infectious complications in these patients. PI hypothesizes that trauma patients with cirrhosis will have higher rates of mortality and infectious complications.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Cirrhotic trauma patients in the United States within 2010-2018
  • Patients ≥ 18 years old

Exclusion criteria

  • Patients less than 18 years old

Treatment and study plan

Primary outcomes

  1. Mortality

    Time frame: 2010-2018

    Patient death

  2. Incidence of infectious complications

    Time frame: 2010-2018

    Incidents of complications with infections

Secondary outcomes

  1. Patient demographics

    Time frame: 2010-2018

    demographics of patients

  2. vital signs; clinical measurements

    Time frame: 2010-2018

    clinical measurements

  3. vital signs; pulse rate

    Time frame: 2010-2018

    pulse rate (bpm)

  4. vital signs; temperature

    Time frame: 2010-2018

    temperature

  5. vital signs; respiration rate

    Time frame: 2010-2018

    respiration rate

  6. vital signs; blood pressure

    Time frame: 2010-2018

    blood pressure

  7. injury characteristics

    Time frame: 2010-2018

    characteristics of injuries

  8. hospital and ICU lengths of stay

    Time frame: 2010-2018

    length of days patients stays in hospital/ICU

  9. transfusion data

    Time frame: 2010-2018

    data regarding transfusions

  10. alcohol use indicator

    Time frame: 2010-2018

    indicator of alcohol use

  11. drug use indicator

    Time frame: 2010-2018

    indicator of drug use

  12. ventilator days

    Time frame: 2010-2018

    days on ventilator

  13. Abbreviated Injury Scale

    Time frame: 2010-2018

    abbreviated injury scale score

  14. Glasgow Coma Scale

    Time frame: 2010-2018

    glasgow coma scale score

  15. Injury Severity Score

    Time frame: 2010-2018

    score of injury

  16. discharge date

    Time frame: 2010-2018

    date of discharge

  17. arrival date

    Time frame: 2010-2018

    date of arrival

Sponsors and collaborators

Lead sponsor

Methodist Health System

Other

Registry information

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Dec 28, 2021
Registry last updated
Jun 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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