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Completed

NCT Number: NCT02881996

The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis

The objective of this study is to evaluate two standard post-operative pain regimens routinely used after laparoscopic appendectomy for perforated appendicitis. The investigators hypothesize that the use of intravenous (IV) acetaminophen in addition to IV ketorolac with narcotic pain pump will decrease time to transition off patient/nurse controlled analgesia (PCA) to oral pain medications.

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Key information

Conditions

Perforated Appendicitis Appendicitis Cecal Diseases Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Infections Intestinal Diseases Intraabdominal Infections Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

2 year–17 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Children's Mercy Hospital

Kansas City, Missouri, 64108, United States

About this study

To assess pain control, patient and family perception of pain control, time to return of bowel function defined as passage of first flatus (in days), doses of anti-emetic medications, doses of narcotic pain medications, time to toleration of regular diet (in days), narcotic associated adverse effects (nausea, emesis, respiratory depression, constipation), length of stay, and overall hospital cost in admission.

Post-hospitalization the investigators will assess complications including number and reasons for emergency visits and abscess formation, length of post-hospitalization analgesic use, length of post-hospitalization narcotic use, and time to return to school.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients ages 2-17 years old undergoing laparoscopic appendectomy at CMH found to have perforated appendicitis.

Exclusion criteria

  • Non-perforated appendicitis
  • Normal appendix at the time of operation or other associated conditions causing abdominal pain
  • Patients with history of chronic pain
  • Known underlying liver disorders
  • Known allergy to pain medication in protocol
  • Non-English speaking

Treatment and study plan

IV tylenol

Drug

IV tylenol given scheduled in addition to standard PCA

Other names: acetaminophen,

No IV tylenol

Drug

No additional IV Tylenol given

Ketorolac

Drug

both groups receive as part of our standard postop pain protocol after all operations

Other names: toradol

Primary outcomes

  1. Time Until PCA Discontinued After the Operation

    Time frame: 4 days

    The investigators hypothesize that the use of intravenous (IV) acetaminophen in addition to IV ketorolac with narcotic pain pump will decrease time to transition off PCA/NCA to oral pain medications.

Secondary outcomes

  1. Postoperative Duration of Hospital Stay

    Time frame: 1 week

    The investigators will measure postoperative time to discharge

Sponsors and collaborators

Lead sponsor

Children's Mercy Hospital Kansas City

Other

Registry information

Official study title

Impact of IV Acetaminophen on Post-operative Pain After Laparoscopic Appendectomy for Perforated Appendicitis: A Prospective Randomized Trial

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Aug 29, 2016
Registry last updated
Jan 12, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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