The Impact of Inflammatory Adhesion on the Prognosis of Colon Cancer Patients

The purpose of this study is to explore the impact of tumor-associated inflammatory adhesion on the prognosis of colon cancer patients.

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Key information

Conditions

Colon Cancer Colonic Diseases Colonic Neoplasms Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Cancer Hospital Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, 100021, China

About this study

In some colon cancer patients, although adhesions between the tumor tissue and surrounding organs are found during surgery, postoperative pathology confirms that the tumor has not directly invaded the adhered organs; instead, the adhesions are caused by tumor-associated inflammation. This condition is defined as tumor-associated inflammatory adhesion.

Currently, the impact of tumor-associated inflammatory adhesion on patient prognosis is still unclear. This study aims to explore the impact of tumor-associated inflammatory adhesion on the prognosis of colon cancer patients through the Surveillance, Epidemiology, and End Results (SEER) and Chinese multi-center databases.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

The patient was pathologically diagnosed as colon adenocarcinoma by endoscopic biopsy before operation.
All patients were considered to have tumors invading adjacent organs during surgery
All patients underwent radical surgery.

Exclusion criteria

Patients with distant metastasis, recurrent colon cancer and pT4b CRC were excluded.

Treatment and study plan

This was a retrospective study and no patient intervention was performed.

Other

This was a retrospective study and no patient intervention was performed.

Primary outcomes

Overall survival time (OS)

Time frame: up to 10 years

OS, defined as the time from the first diagnosis to death from any cause or the last follow-up for surviving patients
Cancer-specific survival time (CSS)

Time frame: up to 10 years

CSS refers to the duration from diagnosis of a tumor until the patient succumbs to the tumor, excluding deaths from other causes.
Recurrence free survival time (RFS)

Time frame: up to 10 years

RFS is the time from the time a patient achieved R0 resection after surgery to the time of recurrence or the end of follow-up.

Sponsors and collaborators

Lead sponsor

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Other

Registry information

Official study title

The Impact of Tumor-associated Inflammatory Adhesion on the Prognosis of Colon Cancer Patients: a Study Based on the SEER and Chinese Multi-center Databases

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2024
First posted: Oct 23, 2024
Registry last updated: Nov 7, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed