NCT Number: NCT06874426
In this study, the research team will investigate the incidence and etiology of olfactory dysfunction following endoscopic endonasal skull base surgery, by combining clinical assessments with histomolecular analysis.
Interested in participating?
Request Info18 year–70 year
All sexes
Observational
KU Leuven, Leuven, Vlaams-Brabant, Belgium
The incidence of olfactory dysfunction following endoscopic endonasal skull base surgery remains unclear in current research, and the results vary widely. Additionally, the pathophysiology of this postoperative olfactory dysfunction and the impact of this surgery on the trigeminal system has not been investigated to date. In this study, the investigators developed a state-of-the-art clinical pipeline with olfactory and trigeminal assessments, prior to and following endoscopic endonasal skull base surgery. Furthermore, the investigators will collect surgical waste tissue from the posterior septal mucosa, which is removed during this procedure to gain access to the sphenoid sinus and the (para)sellar region. By performing histomolecular analysis, the research group aims to elucidate the pathophysiology of olfactory dysfunction following this surgery.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
This intervention will be performed as part of the standard-of-care for patients scheduled for endoscopic endonasal skull base surgery for lesions in the (para)sellar region
Other names: endoscopic pituitary surgery, anterior skull base surgery
Time frame: From enrollment to the last evaluation 6 months postoperatively
Time frame: From enrollment to the last evaluation 6 months postoperatively
Time frame: Until the end of study (at 3 years)
Time frame: From enrollment to the last evaluation 6 months postoperatively
Parameters such as smoking history, allergies, age, gender, co-morbidities will be investigated as possible covariates
Contact information is provided by the study sponsor or research team.
Universitaire Ziekenhuizen KU Leuven
Other
Acronym: Endo-Olfact
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