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NCT Number: NCT07488013

The Impact of Early Regular Diet vs Conventional Clear Fluids Regimen on Colorectal Anastomosis

The goal of this clinical trial is to compare the effect of early regular feeding protocol vs conventional clear fluids regimen as per ERAS protocols in patients undergoing colorectal anastomosis. The main questions it aims to answer are:

1. Food tolerance and return of normal bowel Habbits. 2. Rate of Anastomotic leakage 3. Length of hospital stay

Recruiting

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Key information

Conditions

Colorectal Anastomosis

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with a single, primary large bowel anastomosis

Exclusion criteria

  • Patients with large bowel anastomosis and proximal diversion.
  • Patients with severe systemic illnesses or comorbidities that may impact surgical outcomes or dietary tolerance (e.g., severe heart failure, renal failure, liver failure).
  • Patients who require post-operative intensive care unit (ICU) admission or mechanical ventilation
  • Patients with pre-existing conditions that may affect gastrointestinal function or nutrient absorption (e.g., Crohn's disease, malabsorption syndromes).

Treatment and study plan

Regular diet

Behavioral

Regular diet will be initiated within the first 12 hours post-operatively

Clear fluids

Behavioral

Clear fluids will be initiated post-operatively and then gradually updated to regular diet as the patient regains his normal motions

Primary outcomes

  1. Duration of post-operative ileus

    Time frame: from the beginning of the post-operative period up to 30 days

    Duration till the passage of flatus and stool will be documented

  2. Rate of anastomotic leakage

    Time frame: from the beginning of the post-operative period up to 30 days

Secondary outcomes

  1. Length of hospital stay

    Time frame: up to 4 weeks

Study contacts

Contact information is provided by the study sponsor or research team.

Tarek Salem Mabrouk

CONTACT

[email protected]

00201143307034

Sponsors and collaborators

Lead sponsor

Ayman Alayat

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Mar 23, 2026
Registry last updated
Mar 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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