The Impact of Antibiotic Prophylaxis on Incidence of Post-bronchoscopy Fever and Change of Serum Cytokines

Fever can develop after fiberoptic bronchoscopy (FB) in about 2.5 - 16 % of adult patients. We evaluated the impact of oral amoxicillin/clavulanate (AC) on incidence of postbronchoscopic fever and pneumonia.

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Key information

Conditions

Fever Body Temperature Changes Infections Lung Diseases Pathological Conditions, Signs and Symptoms Pneumonia Respiratory Tract Diseases Respiratory Tract Infections Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

About this study

For the population being undergone with bronchoscopy, the clinical signs and procedural measures for complication of bronchoscopy and cytokines will be checked.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

adult patients (aged 18 years or older) who underwent FB

Exclusion criteria

concurrent treatment with antibiotics or systemic corticosteroid

Treatment and study plan

oral amoxicillin/clavulanate 1g (875/125mg)

Drug

oral amoxicillin/clavulanate 1g (875/125mg) on the day of the procedure 30 minutes prior to the FB

Other names: prophylaxis group

Control

Drug

no intervention with the same procedure of FB

Primary outcomes

The incidence of fever

Time frame: 24 hr after bronchoscopy

time frame for body temperature 24hr before and after bronchoscopy every 4hrs

Secondary outcomes

change of serum cytokines level

Time frame: before bronchoscopy and 24hr after bronchoscopy

Time frame for cytokine measurement 24hr before brochoscopy - 1hr after bronchosocpy - 24hr after brochoscopy

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Important dates

Study start: 2008
Primary completion: 2009
Study completion: 2010
First posted: Mar 18, 2010
Registry last updated: Jul 21, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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