The Impact of an Adaptive Patient-centered Web Application on Medication Optimization in HFrEF Patients

The investigators have developed an adaptive medication optimization web application, named SmartHF, that provides patients with tailored information about potential HFrEF GDMT optimization. SmartHF guides patients to share the GDMT optimization recommendations with their provider during a clinic visit.

Participants will be randomized to receive the web application intervention or control up to 30 days before a clinic visit in a 1:1 manner and followed for 12 weeks after the clinic visit. This trial will determine the efficacy of SmartHF in prescribing GDMT in HFrEF patients compared to controls.

Inclusion criteria

• Age 18 years and older at screening
• Diagnosis of heart failure with a left ventricular ejection fraction (LVEF) </= 40% (HFrEF)
• Have a general medicine provider or general cardiology provider for HFrEF
• Have internet access and access to their health system's patient portal
• Fluent in spoken and written English
• At least two of the following: systolic blood pressure ≥ 110mmg, potassium ≤ 5.5, serum creatinine ≤ 2.5, heart rate ≥ 70
• At least two eligible heart failure therapies (guideline-recommended BB, RASI, MRA, or SGLT2i) not yet initiated or below 50% of the target dose

Exclusion criteria

• End-stage HF (hospice candidate)
• Actively treated cancer, except non-melanoma skin cancer
• Implanted ventricular assist device
• Current treatment with chronic inotropic therapy
• Patient's provider for HFrEF care is considered an advanced HF specialist
• Currently pregnant or intends to become pregnant during the study period
• Dialysis