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Completed

NCT Number: NCT05033665

The Impact of Adequate Water Intake on Exercise Performance and Mood in Women and Men

Dehydration is defined as the state of water deficit due to excessive water losses and/or small water intake. Underhydration is the result of inadequate water intake leading to activation of water hormonal homeostasis, characterized by elevated vasopressin, lower urinary output, and concentrated urine without any measurable changes in total body water. It is well established that dehydration (water deficit) decreases exercise performance and worsens mood, mainly in women. However, the impact of increased water intake in underhydrated individuals on their exercise capacity and mood is not known.

The aim of the proposed study is to investigate the impact of increased water intake in underhydrated individuals on aerobic exercise performance and mood in both women and men.

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Key information

Conditions

Dehydration Metabolic Diseases Mood Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Water-Electrolyte Imbalance

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Interdisciplinary Science and Technology Building 8

Phoenix, Arizona, 85004, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adults
  • Residence in Arizona

Exclusion criteria

  • Use of diuretics
  • Use of anti-depressive medication
  • Current pregnancy or lactation
  • Current use of injectable insulin
  • Diagnosed with irritable bowel syndrome
  • Do not pass the Physical Activity Readiness Questionnaire for Everyone (PAR-Q) screening

Treatment and study plan

Increase water consumption

Behavioral

The underhydrated individuals will be instructed to increase their water intake for one week in order to meet the following two criteria: a) urinate at least 7 times per day and b) have straw-like color urine. A 2-mile run will be completed before and after the 7-day intervention.

Maintain adequate water consumption

Behavioral

The subjects that are classified as euhydrated will be asked to maintain high water intake for one week to ensure proper hydration. A 2-mile run will be completed before and after the 7-day intervention.

Primary outcomes

  1. 2-mile run-time (min)

    Time frame: Day 1

  2. 2-mile run-time (min)

    Time frame: Day 8

  3. Mood

    Time frame: Pre-trial on day 1

    Profile of Mood States questionnaire (POMS 2®-Adult Short, Multi-Health Systems Inc.)

  4. Mood

    Time frame: Post-trial on day 1

    Profile of Mood States questionnaire (POMS 2®-Adult Short, Multi-Health Systems Inc.)

  5. Mood

    Time frame: Pre-trial on day 8

    Profile of Mood States questionnaire (POMS 2®-Adult Short, Multi-Health Systems Inc.)

  6. Mood

    Time frame: Post-trial on day 8

    Profile of Mood States questionnaire (POMS 2®-Adult Short, Multi-Health Systems Inc.)

  7. Urine osmolality (mmol/kg)

    Time frame: 4 - 8 PM on day 0

  8. Urine osmolality (mmol/kg)

    Time frame: 4 - 8 PM on day 7

  9. Urine osmolality (mmol/kg)

    Time frame: Upon waking (first morning sample) on day 1

  10. Urine osmolality (mmol/kg)

    Time frame: Upon waking (first morning sample) on day 8

  11. Urine specific gravity

    Time frame: 4 - 8 PM on day 0

  12. Urine specific gravity

    Time frame: 4 - 8 PM on day 7

  13. Urine specific gravity

    Time frame: Upon waking (first morning sample) on day 1

  14. Urine specific gravity

    Time frame: Upon waking (first morning sample) on day 8

Secondary outcomes

  1. Urine color

    Time frame: 4 - 8 PM on day 0

    Armstrong validated 8-color scale. Minimum score: 1. Maximum score: 8. A higher score indicates a worse outcome (e.g., dehydrated).

  2. Urine color

    Time frame: 4 - 8 PM on day 7

    Armstrong validated 8-color scale. Minimum score: 1. Maximum score: 8. A higher score indicates a worse outcome (e.g., dehydrated).

  3. Urine color

    Time frame: Upon waking (first morning sample) on day 1

    Armstrong validated 8-color scale. Minimum score: 1. Maximum score: 8. A higher score indicates a worse outcome (e.g., dehydrated).

  4. Urine color

    Time frame: Upon waking (first morning sample) on day 8

    Armstrong validated 8-color scale. Minimum score: 1. Maximum score: 8. A higher score indicates a worse outcome (e.g., dehydrated).

  5. Thirst perception

    Time frame: 4 - 8 PM on day 0

    175 mm visual analog scale. Minimum score: 0 (not thirsty at all). Maximum score: 175 (extremely thirsty). A higher score indicates a worse outcome (e.g., more thirsty).

  6. Thirst perception

    Time frame: 4 - 8 PM on day 7

    175 mm visual analog scale. Minimum score: 0 (not thirsty at all). Maximum score: 175 (extremely thirsty). A higher score indicates a worse outcome (e.g., more thirsty).

  7. Thirst perception

    Time frame: Upon waking (first morning sample) on day 1

    175 mm visual analog scale. Minimum score: 0 (not thirsty at all). Maximum score: 175 (extremely thirsty). A higher score indicates a worse outcome (e.g., more thirsty).

  8. Thirst perception

    Time frame: Upon waking (first morning sample) on day 8

    175 mm visual analog scale. Minimum score: 0 (not thirsty at all). Maximum score: 175 (extremely thirsty). A higher score indicates a worse outcome (e.g., more thirsty).

Sponsors and collaborators

Lead sponsor

Arizona State University

Other

Registry information

Acronym: WEXMO

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
Sep 5, 2021
Registry last updated
Aug 24, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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