Skip to main content
OpenTrials
Completed

NCT Number: NCT06856629

The Immediate Physiological and Perceptual Response to Blood-flow Restricted Strength Training With Eccentric Loading

Decreasing workloads in strength training makes it more tolerable for a broad range of people. When designed as blood-flow restriction training, similar gains in strength and muscle mass are achieved compared to traditional training. Adding high training loads to blood-flow restriction training only in the eccentric phase (BFR-ECC) might achieve superior gains in muscle strength while still maximizing tolerability of the training stimuli.

This study aims to investigate the acute physiological and perceptual response of blood-flow restriction training with eccentric loading in comparison to traditional eccentric training. The study recruits healthy individuals ≥ 18 years.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Healthy

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Zurich

Zurich, 8001, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinically Healthy

Exclusion criteria

  • Physical or intellectual impairment precluding informed consent or protocol adherence
  • Pain during exercise of any origin
  • History of thromboembolic event in the lower extremity
  • Known pregnancy (no testing is carried out)

Treatment and study plan

Eccentric blood-flow restriction training

Other

Eccentric blood-flow restriction training

Eccentric free-flow training

Other

Eccentric free-flow training

Primary outcomes

  1. minute ventilation

    Time frame: During the intervention (i.e., exercise) for 10 minutes

    recorded with breath-by-breath analysis

Secondary outcomes

  1. Other variables from breath-by-breath analysis

    Time frame: During the intervention (i.e., exercise) for 10 minutes

    VO2, VCO2, RER, breath rate, heart rate

  2. Rate of perceived exertion

    Time frame: Immediately after the intervention (i.e., exercise)

    Numeric rating scale from 0-10. Participants rate perceived leg exertion and perceived respiratory exertion

  3. Near-infrared spectroscopy of the vastus lateralis

    Time frame: During the intervention (i.e., exercise) for 10 minutes

    Tissue saturation

  4. Delayed onset muscle soreness

    Time frame: 24, 48, and 72 hours after each of the intervention (i.e., exercise)

    Numeric rating scale 0-10 rating intensity of DOMS symptoms

  5. Feasibility and tolerability

    Time frame: After study completion (i.e., after the second study visit, up to 2 weeks)

    Custom-made questionnaire

Sponsors and collaborators

Lead sponsor

Dario Kohlbrenner

Other

Registry information

Official study title

The Immediate Physiological and Perceptual Response to Blood-flow Restricted Strength Training With Eccentric Loading (E-BFR): a Randomised Crossover Study in Healthy Subjects

Acronym: E-BFR

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Mar 4, 2025
Registry last updated
Jul 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.