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NCT Number: NCT06565325

The Immediate Effect of Combined Terminal Knee Extension Exercise With Audible Cues

Typically, patients perform TKE by themselves after exercise prescription. The investigators thought that a lack of attention and preferred speed of patients might not provide the best outcome. Therefore, an increased effectiveness of TKE is interesting for physical therapy implication. Besides, adding sensory input which is audible cues or rhythm during exercise may enhance the efficacy of the exercise by increasing neuromuscular control and function.

Therefore, the study aimed to investigate the immediate effects of combined TKE with audible cues on motor unit behavior. The researchers expect that adding rhythm from the metronome will enhance neuromuscular control which may change motor unit behavior of VM muscle. The findings of the study may have helped explain the mechanism behind the acute effects of combined TKE with audible cues on VM function and their potential application in the field of physical therapy.

This study aims to investigate the immediate effect of combined TKE with audible cues on motor unit behavior in healthy participants and to investigate reliability of decomposition electromyography procedure during single leg squat.

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Key information

Conditions

Muscle Weakness Muscular Diseases Musculoskeletal Diseases Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Physical Therapy, Mahidol University

Nakhon Pathom, Salaya, 73170, Thailand

About this study

A metronome will be used to provide rhythmic exercise. Participants will stand with their feet in line with their shoulders as starting position and straping at the knee. Exercise intensity is 60% of the 1RM weight. At the beginning of the exercise, participants will be asked to bend their knees following the pull of the resistance and exert force to straighten the knee (10 times/set and 3 sets). 180 seconds of resting will be allowed between sets.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged range between 18 and 30 years
  • BMI of 18.5-25 kg/m2
  • Male or female
  • Lightly active or sedentary {Physical activity level (PAL= 1.4-1.69)}

Exclusion criteria

  • History of serious injury or operation of lower back and lower extremities such as fracture
  • Musculoskeletal problems of lower back and lower extremities in 6 months before the study
  • Single-leg stance test < 43 seconds (26). and range of weight-bearing lunge test < 9.1 cm

Treatment and study plan

Exercise + Audible Cues

Behavioral

Combined Terminal Knee Extension Exercise with Audible Cues

Other names: Metronome

Exercise

Behavioral

Terminal Knee Extension Exercise

Primary outcomes

  1. Motor unit firing rate

    Time frame: At the end of Cycle 1 (each cycle is 1 day)

    one parameter to explain the motor unit behavior of vastus medialis muscle

  2. Peak motor action potential

    Time frame: At the end of Cycle 1 (each cycle is 1 day)

    one parameter to explain the motor unit behavior of vastus medialis muscle

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Official study title

The Immediate Effect of Combined Terminal Knee Extension Exercise With Audible Cues on Vastus Medialis Muscle Motor Unit Behavior in Healthy Individuals

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 21, 2024
Registry last updated
Jul 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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