The Ohio State University Human Nutrition Laboratory
Columbus, Ohio, United States
NCT Number: NCT02841618
The purpose of this study is to understand how consuming healthy cookies every day for two weeks will affect different types of fat in the blood. Specifically, the overall goal of this study is to find out if the healthy cookies can increase a polyunsaturated fat called linoleic acid in plasma, red blood cells and white blood cells.
This study is active but is not currently recruiting participants.
Notify Me18 year–80 year
All sexes
Interventional
Not applicable
Columbus, Ohio, United States
Overall, linoleic acid has many health benefits including altering body composition and energy metabolism, possibly through its impact on cardiolipin. It is therefore imperative to develop foods products that allow for Americans to easily increase their intake of linoleic acid. It's also important to understand the mechanism in which linoleic acid exerts these positive health effects, particularly in states of muscle mass and quality loss associated with mitochondria dysfunction.
The investigators plan to test the central hypothesis and accomplish the overall objective of this research by pursuing the following three specific aims
Aim 1: To determine the extent to which cookies, made with grapeseed oil , increase linoleic acid in plasma, red blood cells (RBCs), and peripheral blood mononuclear cells (PBMCs) fraction of blood after two weeks consumption
Aim 2: To determine the extent to which cookies, made with grapeseed oil, increase cardiolipin and linoleic acid content of cardiolipin in PBMCs after two weeks of consumption
Aim 3: To determine and compare the acceptability of consuming cookies made with grapeseed oil or high oleic safflower oil every day for two weeks
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Time frame: Baseline through Week 02
Linoleic acid content of fasting blood samples
Time frame: Baseline through Week 02
Cardiolipin content in fasting blood samples
Time frame: Baseline through Week 02
9-point sensory evaluation of healthy cookies
Time frame: Baseline through Week 02
grip strength measurement
Time frame: Baseline through Week 02
gait speed measurement
Time frame: Baseline through Week 02
Body Mass Index measurement
Time frame: Baseline through Week 02
Abdominal thickness measurement
Time frame: Baseline through Week 02
Sleeping questionnaire
Time frame: Baseline through Week 02
Physical Activity questionnaire
Time frame: Baseline through Week 02
omega-3 fat intake questionnaire
Ohio State University
Other
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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