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Completed

NCT Number: NCT02479152

The Haemodynamic Effects of Mechanical Standard and Active Chest Compression-decompression During Out-of-hospital CPR

The aim of this randomized out-of-hospital cardiopulmonary resuscitation study is to investigate haemodynamics generated by the standard mechanical external chest compression device (LUCAS™ 2) compared to a new version generating chest compressions and active decompression above the initial starting position of the suction cup (LUCAS™ 2AD).

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Key information

Conditions

Cardiac Arrest Cardiovascular Diseases Heart Arrest Heart Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Oslo University hospital

Oslo, 0467, Norway

About this study

Based on randomization patients will receive standard or active compression decompression chest compression and the haemodynamic effects will be compared.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Unexpected adult out-of-hospital non-traumatic cardiac arrest where an attempt of resuscitation is considered appropriate in:
  • Patients 18 years or older

Exclusion criteria

  • Traumatic cardiac arrest
  • Age believed to be less than 18 years
  • Known pregnancy
  • Victim not to be resuscitated (DNR orders)
  • Internals in prison
  • Included once in the study already
  • To Small/Large patients
  • Sustained ROSC occurring before the LUCAS™ 2 or LUCAS™ 2-AD can be applied to the patient, such that further CPR is not needed

Treatment and study plan

LUCAS2 AD

Device

LUCAS™ 2AD with compressions like the standard LUCAS™ 2 but added decompressions above the initial start position.

Primary outcomes

  1. Hemodynamics measured as EtCO2

    Time frame: During 30 minutes of CPR

Secondary outcomes

  1. Intra arterial blood pressures,

    Time frame: During 30 minutes of CPR

  2. Oximetry,

    Time frame: During 30 minutes of CPR

  3. ROSC (Return of spontaneous circulation)

    Time frame: During CPR

  4. safety

    Time frame: During 30 minutes of CPR

Sponsors and collaborators

Lead sponsor

Physio-Control

Industry

Collaborators

  • GE Healthcare

Registry information

Official study title

The Haemodynamic Effects of Mechanical Standard and Active External Chest Compression-decompression During Out-of-hospital Cardiopulmonary Resuscitation

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Jun 24, 2015
Registry last updated
Aug 4, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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