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Completed

NCT Number: NCT03868683

The Glycemic Effect of Added Sugar on Bake Beans

To investigate the effect of added sugar to bake beans on glycemic and insulinemic response.

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Key information

Conditions

Diabetes Mellitus, Type 2 Body Weight Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms PreDiabetes Prediabetic State Signs and Symptoms

Age range

21 year–60 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Clinical Nutrition Research Centre

Singapore, 117599

About this study

There will be a total of 7 test session. Each session will last for 3 hours. At each test session, volunteers will be served with 7 test meals and blood will be collected. After an overnight fast, subjects will visit the research center. Two fasting capillary blood samples will be collected via fingerpick. Following the fasting samples, volunteers will consume the test meals. Further blood samples will be collected at 15, 30, 45, 60, 90, 120, 150, 180 minutes after the ingestion of test meal. These samples will be used to analyses for whole capillary blood glucose. At every 30 minute interval, samples will be collected for analysis of capillary plasma insulin.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Chinese ethnicity
  • Age ≥21 and ≤ 60 years
  • Body mass index between 18.5 to 25 kg/m2
  • Normal blood pressure <140/90 mmHg
  • Fasting blood glucose <6.0 mmol/L
  • In general good health

Exclusion criteria

  • Current Smoker
  • have any metabolic diseases (such as diabetes, hypertension etc)
  • have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
  • having medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
  • have intolerances or allergies to any foods
  • partake in sports at the competitive and/or endurance levels
  • intentionally restrict food intake

Treatment and study plan

Glucose Reference 1

Other

30 g of glucose dissolved in 250 ml of water

Glucose Reference 2

Other

30 g of glucose dissolved in 250 ml of water

Glucose Reference 3

Other

30 g of glucose dissolved in 250 ml of water

Sucrose

Other

30 g of Sucrose dissolved in 250 ml of water

Regular Bake beans in tomato sauce

Other

Bake beans in tomato sauce containing 14 g of sugar

Bake beans in tomato sauce, reduced sugar

Other

Bake beans in tomato sauce containing 12.2 g of sugar

Bake beans in tomato sauce, low GI

Other

Bake beans in tomato sauce containing 7.2 g of sugar

Primary outcomes

  1. Glucose [

    Time frame: Up to 180 minutes

    Whole capillary blood glucose will be measure using Hemocue analyser

Secondary outcomes

  1. Insulin

    Time frame: Up to 180 minutes

    Capillary plasma will be measure using Cobas analyser

Sponsors and collaborators

Lead sponsor

Singapore Institute of Food and Biotechnology Innovation

Other Gov

Registry information

Acronym: GIF

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Mar 11, 2019
Registry last updated
Jul 17, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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