The Geneva Lake Study Update : An Overview of Home Non-Invasive Ventilation 15 Years Later

Diagnosis leading to NIV. 5 disease categories with identification of the percentage of patients with SRBD, COPD, Overlap syndrome, OHS, NMD, restrictive chest wall and lung disorders. All data were analyzed using descriptive statistics. Qualitative parameters were described as frequencies and percentages and quantitative parameters were described as mean and standard deviation (SD) or as median and interval interquartile (IQR). Comparisons between groups were performed using chi-square tests or Fisher exact tests for qualitative parameters and analysis of variance (one-way ANOVA) or Kruskal-Wallis tests for quantitative parameters, as appropriate.

Comorbidities, age, gender. All data were analyzed using descriptive statistics. Qualitative parameters were described as frequencies and percentages and quantitative parameters were described as mean and standard deviation (SD) or as median and interval interquartile (IQR). Comparisons between groups were performed using chi-square tests or Fisher exact tests for qualitative parameters and analysis of variance (one-way ANOVA) or Kruskal-Wallis tests for quantitative parameters, as appropriate.

Analyze short-term mortality rate and risk factors. All data were analyzed using descriptive statistics. Qualitative parameters were described as frequencies and percentages and quantitative parameters were described as mean and standard deviation (SD) or as median and interval interquartile (IQR). Comparisons between groups were performed using chi-square tests or Fisher exact tests for qualitative parameters and analysis of variance (one-way ANOVA) or Kruskal-Wallis tests for quantitative parameters, as appropriate.

Investigate modifiable and non-modifiable risk factors asssociated with non intentional air leaks during home non invasive ventilation (NIV). Air leaks are identified by the built in software of the ventilator and clinicians download these data onto a computer. Leaks are expressed in ml or liters. All data were analyzed using descriptive statistics. Qualitative parameters were described as frequencies and percentages and quantitative parameters were described as mean and standard deviation (SD) or as median and interval interquartile (IQR). Comparisons between groups were performed using chi-square tests or Fisher exact tests for qualitative parameters and analysis of variance (one-way ANOVA) or Kruskal-Wallis tests for quantitative parameters, as appropriate.

Is NIV implemented electively or urgently (yes versus no), in an outpatient or input setting (yes vs no), by liberal pulmonologist or hospital center (yes vs no). Data with binary outcome. All data were analyzed using descriptive statistics. Qualitative parameters were described as frequencies and percentages and quantitative parameters were described as mean and standard deviation (SD) or as median and interval interquartile (IQR). Comparisons between groups were performed using chi-square tests or Fisher exact tests for qualitative parameters and analysis of variance (one-way ANOVA) or Kruskal-Wallis tests for quantitative parameters, as appropriate.

Arterial blood gas (ABG): pH, pCO2 (kPa), pO2 (kPa), HCO3 (mmol/l), base excess (mmol/l), SpO2 (%), spirometry: FEV1/FVC % of predicted, FEV1 % of predicted, FVC % of predicted, pulsoxicapnometry: SpO2 (%), time with SpO2 < 90% (%), desaturation index > 3 (%), pCO2 (kPa). All data were analyzed using descriptive statistics. Qualitative parameters were described as frequencies and percentages and quantitative parameters were described as mean and standard deviation (SD) or as median and interval interquartile (IQR). Comparisons between groups were performed using chi-square tests or Fisher exact tests for qualitative parameters and analysis of variance (one-way ANOVA) or Kruskal-Wallis tests for quantitative parameters, as appropriate.

Home ventilators used (ASV vs barometric vs volumetric), settings: minimal and maximal pressure support (cmH2O), fixed EPAP (cmH20), minimal and maximal EPAP (cmH2O), back-up respiratory rate (cycles/min), data downloaded from the device software: EPAP (cmH2O), IPAP (cmH2O), EPAP 90% (cmH2O), mean pressure support (cmH2O), tidal volume (ml), minute ventilation (L/min), leaks (L/min), apnea index (N/hour), apnea-hypopnea index (N/hour), mean daily use (min/day), interfaces (facial vs nasal vs prongs masks), duration to therapy (expressed in hours). All data were analyzed using descriptive statistics. Qualitative parameters were described as frequencies and percentages and quantitative parameters were described as mean and standard deviation (SD) or as median and interval interquartile (IQR).

Prevalence of home non invasive ventilation. All data were analyzed using descriptive statistics. Qualitative parameters were described as frequencies and percentages and quantitative parameters were described as mean and standard deviation (SD) or as median and interval interquartile (IQR). Comparisons between groups were performed using chi-square tests or Fisher exact tests for qualitative parameters and analysis of variance (one-way ANOVA) or Kruskal-Wallis tests for quantitative parameters, as appropriate.

Sub-analysis groups depending on the type of home NIV (barometric and volumetric ventilation versus ASV). All data were analyzed using descriptive statistics. Qualitative parameters were described as frequencies and percentages and quantitative parameters were described as mean and standard deviation (SD) or as median and interval interquartile (IQR). Comparisons between groups were performed using chi-square tests or Fisher exact tests for qualitative parameters and analysis of variance (one-way ANOVA) or Kruskal-Wallis tests for quantitative parameters, as appropriate.

To study if there is a statistical significance in the outcomes listed above (diagnostic groups, comorbidities) depending if the medical follow-up is done by a liberal pulmonologist or a hospital center. All data were analyzed using descriptive statistics. Qualitative parameters were described as frequencies and percentages and quantitative parameters were described as mean and standard deviation (SD) or as median and interval interquartile (IQR). Comparisons between groups were performed using chi-square tests or Fisher exact tests for qualitative parameters and analysis of variance (one-way ANOVA) or Kruskal-Wallis tests for quantitative parameters, as appropriate.