Completed

NCT Number: NCT02225119

The Focal Electro-Oculogram in Macular Disease

Background:

- Maculopathies are eye conditions that affect the center of the retina. Retina health depends on the retinal pigment epithelium (RPE), a layer behind the retina. A new test may measure the health of the central retina and RPE.

Objective:

- To use the focal electro-oculogram (EOG) test to understand how the central retina and RPE are affected in maculopathies.

Eligibility:

* People at least 10 years old with a maculopathy. * Healthy volunteers with visual acuity of 20/20 or better in at least one eye.

Design:

* Participants will be screened with medical and eye history and an eye exam. Pictures will be taken of the eyes. * Their eyes may be dilated. * They may have a field test. They will look into a lens and press a button when they see a light. First, they may sit in the dark for 40 minutes. * Participants will have 1-7 visits over 18 months. * Their vision will be tested and eye pressure measured. * Their pupils will be dilated with eye drops and researchers may take pictures of the retina and the inside of the eye, and measure the thickness of the retina. * Participants will have an electro-oculogram. They will look at a 2 LED lights and follow them back and forth for 10 seconds once per minute. Participants will be in darkness for 15 minutes and in light for 20 minutes. One skin electrode will be placed on the nose and one next to the eye. * Participants with maculopathy will also have: * Field test. * Electroretinogram. Participants will get numbing eye drops and special contact lenses. A small metal electrode will be taped to the forehead. Participants will watch flashing lights and try not to blink. First, they may sit in the dark for 40 minutes.

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Key information

Conditions

Macular Degeneration Age-Related Macular Degeneration Eye Diseases Retinal Degeneration Retinal Diseases

Age range

10 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

About this study

OBJECTIVE:

The objective of this protocol is to investigate the local response of the retinal pigment epithelium (RPE) across the posterior pole of the eye by recording the focal electrooculogram (EOG) in participants with macular disease.

STUDY POPULATION:

Up to 50 healthy volunteers and 80 participants, age 10 or older, with macular disorders affecting the retina/retinal pigment epithelium complex. Examples of such macular disorders include Stargardt s disease and age-related macular degeneration (AMD).

DESIGN:

This single-center, observational, case-control study will be comprised of three related aims. The first aim is focused on developing the focal EOG method which will require parameter optimization. The second aim is focused on establishing the normal range and variability of the focal EOG in normal volunteers. The third aim is to examine the focal EOG in participants with macular disease.

OUTCOME MEASURES:

The primary outcome for this study is to develop a method for recording the focal EOG. The secondary outcome will be to establish the normal range for the focal EOG and determine the inter-session and intra-session variabilities of this test. Exploratory outcomes include: 1) to examine the focal EOG in participants with macular diseases and 2) determine the inter-session and intra-session variabilities of this test in participants with macular diseases.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

INCLUSION CRITERIA:

Participant must be 10 years of age or older.
Participant (or legal guardian) must understand and sign the protocol s informed consent document.
Participant must be able to cooperate with the testing required for this study.
For Participants with macular disease only:

Participant must have macular disease, defined as evidence of loss of centrally mediated retinal dysfunction and/or degeneration as established by standard clinical methods including perimetry, ERG and imaging.
Participant must have a measurable visual acuity.
For Healthy Volunteers only:

Participant must have visual acuity of 20/20 or better in at least one eye.

Exclusion criteria

Participant with pre-retinal media opacities that would prevent focal light presentation.

Treatment and study plan

Primary outcomes

develop method for recording focal EOG

Time frame: up to 6 months

to develop a method for recording the focal EOG in response to a central light stimulus

Secondary outcomes

establish the normal range for the focal EOG and determine the inter-session and intra-session variabilities of this test

Time frame: up to 18 months

establish the normal range for the focal EOG and determine the inter-session and intra-session variabilities of this test

Sponsors and collaborators

Lead sponsor

National Eye Institute (NEI)

Nih

Registry information

Important dates

Study start: 2015
Primary completion: 2019
Study completion: 2020
First posted: Aug 26, 2014
Registry last updated: Dec 11, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed