The FEMA Study: Feasibility of Exercise in Patients With Metastatic Breast Cancer and Adiposity

Recruitment rate calculated by the amount of included partcipants of those eligible

Adherence to the training program assessed by the mean attendance rate

Retention rate to the study assessed by the proportion of participants in each study arm that completes the study period

Adherence to other study procedures assessed by the proportion of completed questionnaires and blood samples at the specified time-points

Acceptability of the study intervention assessed by the proportion of participants in the intervention arm that anwers "yes" to the question: "Would you recommend others to participate in the physical activity program?"

Change in health-related quality of life measured with European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30. The QLQ-C30 is composed of both multi-item scales and single-item measures. These include five functional scales, three symptom scales, a global health status/QoL scale, and six single items, with 30 items in total. All scales and single-item measures range in score from 0 to 100. A high score on the functional scale represents a high level of functioning, a high score for the global health status represents a high HRQoL, but a high score on a symptom scale represents a high level of symptomatology

Change in metabolic score calculated as the sum of Z-transformed levels of mid-blood pressure [(systolic blood pressure + diastolic blood pressure)/2], glucose, and triglycerides. A higher score indicates a worse metabolic health

Change in self-efficacy in coping with cancer measured with Cancer Behavior Inventory-12 (CBI-12). The questionnaire is scored as a one-dimensional scale, summing the ratings for the items. A higher score indicates higher levels of self-efficacy, with a maximum score of 108.

Change in sleep quality measured with Pittsburgh Sleep Quality Index (PSQI). The questionnaire consists of 19 items grouped into seven component scores. The directionality and interpretation of scores vary across items. A total score ranging from 0 to 21 can be calculated, with a higher score indicating poorer sleep quality. A score < 5 indicates good sleep quality.

Change in insomnia assessed by Insomnia Severity Index (ISI). It contains 7 items and is scored on a one-dimensional scale with a maximum score of 28. The total score is grouped into four categories: no insomnia (0-7), subclinical insomnia (8-14), clinical insomnia (15-21) and severe clinical insomnia (22-28).

Change in circulation levels of C-reactive protein measured in mg/L

Change in circulation levels of total leukocytes measured in 10^9/L

Change in HbA1c measured in mmol/mol

Change in LDL cholesterol measured in mmol/L

Change in HDL cholesterol measured in mmol/L

Change in BMI kg/m^2

Change in fat mass in kilogram

Change in muscle mass in kilogram

Change in visceral fat in kilogram

Change in VO2 max measured by Watt-Max test

Change in handgrip strength in kilogram measured by dynamometer after 12 weeks

Change in number of performed sit-rising in 30 seconds measured through a sitting-rising test