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OpenTrials
Completed

NCT Number: NCT02257190

The Features Behind the Beneficial Effects of Interval-walking

A single bout of Interval-Walking (IW) exercise is superior to energy-expenditure and time-duration matched Continuous Walking (CW) exercise upon improving glycemic control. The reason IW is superior is unknown.

This study will look into whether it is the larger peak intensity during IW or if it is the alternating exercise pattern that is responsible for the larger improvements seen.

Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:

1. One hour of rest (Con) 2. One hour of classical interval walking (repeated cycles of 3 min of fast and 3 min of slow walking; IW3) 3. One hour of fast alternating interval walking (repeated cycles of 1 min of fast and 1 min of slow walking; IW1).

After the interventions subjects will undergo a standardized mixed meal tolerance test, with consecutive measurements of blood glucose, insulin and c-peptide.

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Key information

Conditions

Diabetes Mellitus, Type 2 Behavior Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Motor Activity Nutritional and Metabolic Diseases

Age range

30 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Center for Physical Activity Research (CFAS)

Copenhagen, 2100, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Type 2 diabetes mellitus
  • Body mass index > 18 but < 40 m2/kg
  • Agreement to pause antidiabetic medication from 2 days before to after each trial

Exclusion criteria

  • Pregnancy
  • Smoking
  • Use of exogenous insulin
  • Contraindication to increased levels of physical activity
  • Evidence of thyroid, liver, lung, heart or kidney disease

Treatment and study plan

Control

Behavioral

One hour of rest.

Other names: No exercise

IW3

Behavioral

A one hour exercise bout with repeated cycles of 3 min of fast and 3 min of slow walking

Other names: 'Classical' interval walking, Interval walking - 3 min intervals

IW1

Behavioral

A one hour exercise bout with repeated cycles of 1 min of fast and 1 min of slow walking

Other names: 'Fast alternating' interval walking, Interval walking - 1 min intervals

Primary outcomes

  1. Glycemic control

    Time frame: Within the first 4 hours after the interventions

    Glycemic control will be measured after each intervention. Subjects will receive a standardized mixed meal tolerance test (MMTT), and blood glucose values will be obtained during the test.

Secondary outcomes

  1. Insulin secretion

    Time frame: Within the first 4 hours after the interventions

    Insulin and C-peptide will be measured during the MMTT

  2. Insulin sensitivity

    Time frame: Within the first 4 hours after the interventions

    From the measurements og glucose and insulin during the MMTT, various indices of insulin sensitivity will be assessed

Sponsors and collaborators

Lead sponsor

Rigshospitalet, Denmark

Other

Registry information

Acronym: aIWS2

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Oct 6, 2014
Registry last updated
Oct 29, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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