The Feasibility and Efficacy of an Immersive Virtual Reality Software in Parkinson's Disease Patients

Inclusion criteria

• Patients diagnosed with Parkinson's disease according to MDS criteria;
• Hoehn and Yahr stages between I-III (MED ON);
• Ability to perform the Time Up and Go test in normal pace and without assistance, in less than 11,5 seconds in ON state;
• Stable medication for the past 1 month
• Ability to communicate with the investigator, to understand and comply with the requirements of the study;
• Willing and able to provide written informed consent to participate in the study.

Exclusion criteria

• History of falls (1 fall in the 3 previous months);
• Psychiatric major co-morbidity (e.g., major depressive disorder as determined by DSM IV criteria);
• A Montreal Cognitive Assessment (MoCA) score < 21;
• Significant visual or visual-perceptual deficits or neuropsychological impairments that may limit participation in the protocol;
• Having any other neurological/orthopaedic disorders likely to affect gait or exercise capacity, e.g., history of stroke;
• Unstable medical condition including cardiovascular instability in the past 6 months
• Interfering activities performed at high level (sports);
• Inability to correctly respond to the assessment protocol according to the clinician's judgment or lack of support from caregiver for this effect.