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Completed

NCT Number: NCT06092359

The Eye in Orbit: UCF Adaption

The goal of this study is to understand the impact of space travel on the eyes. Space flight impacts numerous aspects of ocular anatomy and physiology. Current hypotheses are based on pressure changes within and around the optic nerve. Retinal and choroid blood drainage may be affected by microgravity associated cerebrospinal fluid pressure changes. Recently, a new imaging modality, Optical Coherence Tomography Angiography (OCTA), has been able to reveal micro vascular changes in the retina and choroid. To date, no microgravity ocular imaging tests have been published using OCTA. In this study the researchers aim to describe microgravity circadian choroidal and retinal vasculature using multimodal imaging including OCTA to better understand space associated ocular changes.

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Key information

Conditions

Spaceflight Associated Neuro-Ocular Syndrome SANS spaceflight-induced visual impairment

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Central Florida

Orlando, Florida, 32816, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • astronauts in the AX1/Rakia mission, which was scheduled for space flight in late March 2022.

Exclusion criteria

  • adults unable to consent
  • individuals who are not yet adults (infants, children, teenagers) -
  • pregnant women
  • prisoners.

Treatment and study plan

Primary outcomes

  1. To examine early changes in ocular physiology following exposure to microgravity and asses these changes as risk factor for Spaceflight Associated Neuro-Ocular Syndrome (SANS).

    Time frame: 4 months

  2. Asses early changes in ocular physiology as risk factor for Spaceflight Associated Neuro-Ocular Syndrome (SANS).

    Time frame: 4 months

Sponsors and collaborators

Lead sponsor

University of Central Florida

Other

Registry information

Official study title

The Eye in Orbit- Analysis of the Anatomical and Functional Ocular Changes Related to Space Flights: UCF Adaptation.

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Oct 23, 2023
Registry last updated
Dec 6, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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