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OpenTrials
Completed

NCT Number: NCT00706199

The Expression of Antigens in Bone Marrow Samples From Volunteering Donors.

Antigen expression levels in bone marrow from volunteering donors will be analyzed. The results of this analysis will be used to establish a clinical test to identify cancer patients who could qualify to receive an investigational treatment being developed by GlaxoSmithKline.

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Key information

Conditions

Cancer Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

GSK Investigational Site

Ottignies, 1340, Belgium

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The donor is aged >= 18 years
  • Written informed consent has been obtained prior to the performance of any specific procedure.
  • The donor has a medical indication for which a bone marrow aspiration is planned.
  • The donor is eligible for a bone marrow aspiration.

Treatment and study plan

Bone Marrow Aspiration

Procedure

Collection of a 2 ml bone marrow sample from an aspirate carried out for medical purposes.

Primary outcomes

  1. Number of copies of Wilms' Tumor 1 (WT1) antigen expression in bone marrow

    Time frame: At Day 0

    Establishment of the range of WT1 transcript levels in a collection of bone marrow samples by real-time quantitative RT-PCR (Reverse Transcription Polymerase Chain Reaction). Due to the low numbers, they were expressed as [value x 10E-03]. Only the samples with gene expression >0 were presented.

  2. Number of copies of PRAME (Preferentially expressed in melanoma)antigen expression in bone marrow

    Time frame: At Day 0

    Establishment of the range of PRAME transcript levels in a collection of bone marrow samples by real-time quantitative RT-PCR (Reverse Transcription Polymerase Chain Reaction). Due to the low numbers, they were expressed as [value x 10E-03]. Only the samples with gene expression >0 were presented.

Sponsors and collaborators

Lead sponsor

GlaxoSmithKline

Industry

Registry information

Official study title

Analysis of Expression of Antigens in Bone Marrow Samples From Volunteering Donors.

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Jun 27, 2008
Registry last updated
Feb 5, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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