The Exogenous Progesterone Free Luteal Phase After GnRHa Trigger - a Pilot Study in Normo-responder IVF Patients

After hCG trigger a large amount of exogenous progesterone is used for luteal phase support in many countries until 10th week of gestation. Instead we suggest the use of two small doses of hCG after the trigger during the early luteal phase after GnRHa trigger, promoting the endogenous progesterone production from the corpora lutea (CL).

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

20 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

The Fertility Clinic, Regional Hospital of Skive

Skive, 7800, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age between 20 and 40
Normal menstrual cycles: 25-34 days
Oligomenorrhea/amenorrhea or polycystic syndrome (defined according to the Rotterdam criteria 2004)
BMI >18 and <35 kg/m2

Exclusion criteria

Patients with >14 follicles on day of trigger
Previous hyperresponse with OHSS development
Previous low response (less than 3 oocytes on a high dose of FSH stimulation)
Endocrine disorders

Treatment and study plan

HCG

Drug

Progesterone and Estradiol

Drug

Primary outcomes

Ongoing pregnancy rate per patient

Time frame: 10th week of gestation.

Sponsors and collaborators

Lead sponsor

Peter Humaidan

Other

Registry information

Official study title

The Exogenous Progesterone Free Luteal Phase After GnRHa Trigger - a Randomized Controlled Pilot Study in Normo-responder IVF Patients

Acronym: GnRHa trigger

Important dates

Study start: 2014
Primary completion: 2019
Study completion: 2020
First posted: Nov 11, 2013
Registry last updated: Dec 17, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed