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NCT Number: NCT07467486

The EnvScore-Aorte Diagnostic Study Protocol for the Identification of Acute Aortic Syndrome

The goal of this retrospective observational study is to evaluate the diagnostic performance of the AORTAs score integrated with environmental exposure data (AORTAs-E) for the identification of Acute Aortic Syndrome (AAS) during initial maangement in the emergency departement.

The main question it aims to answer is:

Can the integration of real-time meteorological and atmospheric pollution data improve the early identification of AAS in patients presenting in the emergency department for chest, abdominal, or back pain?

Researchers will analyze medical records and environmental data for 580 adult patients (290 cases with confirmed AAS and 290 controls) managed at the University Hospital of Besançon between 2014 and 2026. Environmental exposure, including temperature and pollutant concentrations, will be calculated based on each patient's residential address to determine if adding these factors to clinical data increases diagnostic accuracy.

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Key information

Conditions

Acute Aortic Syndrome Aortic Diseases Cardiovascular Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

(Cases - AAS+) :

  • Adults (>18 years)
  • Diagnosis of AAS (aortic dissection, intramural hematoma, or penetrating atherosclerotic ulcer) identified according to medicalization programs for information systems
  • Diagnosis confirmed by imaging (CTA, TTE, or TOE)

Inclusion criteria

(Controls - AAS-):

  • Adults (>18 years)
  • Presenting in the emergency department for chest, back, or abdominal pain.-
  • Confirmed differential diagnosis by CTA, ruling out AAS

Exclusion criteria

  • Post-traumatic or iatrogenic AAS.
  • Subacute (8-30 days) or chronic symptoms (>30 days).
  • Patients under legal protection or unable to provide consent/non-opposition.

Treatment and study plan

Primary outcomes

  1. Area Under the Receiver Operating Characteristic (ROC) Curve (AUC) of the AORTAs scores.

    Time frame: From January 2014 to January 2026

    Comparison of the diagnostic performance between the four scores: original AORTAs, AORTAs-E (Environmental), AORTAs-R (emergency medical dispatch), and AORTAs-R+E (Combined).

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Besancon

Other

Registry information

Official study title

Diagnostic Performance of a Modified AORTAs Score Integrated With Environmental Exposure Data for Acute Aortic Syndrome Identification : The EnvScore-Aorte Diagnostic Study Protocol

Acronym: EnvScore Aorte

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Mar 12, 2026
Registry last updated
Mar 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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