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NCT Number: NCT07552285

The Enhancement of Diagnostic and Grading Efficacy of Prostate Cancer by New MRI Sequences: A Prospective Observational Study Based on New MRI Sequences in a Single Center

The goal of this clinical trial aims to explore the diagnostic efficacy and grading of prostate cancer by a novel MRI sequences such as MAGiC，OGSE,CEST,IVIM,etc.The main question it aims to answer is:

Can the novel non-contrast multiparametric MRI imaging improve the accuracy of diagnosis and grading of prostate cancer? For patients with clinical suspicion of prostate cancer, both conventional and new sequences magnetic resonance scans are conducted, with surgical or biopsy pathological results serving as the gold standard.

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Key information

Conditions

Prostate Cancer Disease Genital Diseases Genital Diseases, Male Genital Neoplasms, Male Male Urogenital Diseases Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Prostate Cancer (Diagnosis) Prostatic Diseases Prostatic Neoplasms Urogenital Diseases Urogenital Neoplasms

Age range

20 year–90 year

Sex eligibility

Male

Study type

Observational

Primary location

The First Affiliated Hospital of Soochow University

Suzhou, Jiangsu, China

Location status: Recruiting

Location contact

Gang Chen

CONTACT

E-mail:[email protected]

+86 0512 67972861

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with a high clinical suspicion of prostate cancer and elevated tPSA levels;
  • Patients with no prior history of other tumors;
  • Patients with no contraindications to MRI, including claustrophobia, presence of pacemakers, cardiac stents, or metal implants such as screws and plates.

Exclusion criteria

  • The patient has a history of malignant tumors and has received corresponding treatment;
  • Prior to the MRI examination, the patient has undergone treatment for prostate cancer, including endocrine therapy, radiotherapy, etc.;
  • Patients who have previously undergone radical prostatectomy for prostate cancer.

Treatment and study plan

observational study

Other

The researchers will conduct observations, collect data and conduct follow-ups on the participants, but will not actively alter their treatment or health conditions.

Primary outcomes

  1. Microstructure parameters related to the OGSE sequence

    Time frame: Within one week after the MRI scan

  2. CEST sequence-related numerical values

    Time frame: Within one week after the MRI scan

  3. MAGIC sequence-related numerical values

    Time frame: Within one week after the MRI scan

  4. IVIM sequence-related numerical values

    Time frame: Within one week after the MRI scan

Secondary outcomes

  1. Regular sequence-related numerical values

    Time frame: Within one week after the MRI scan

Study contacts

Contact information is provided by the study sponsor or research team.

Qian Zhang

CONTACT

[email protected]

+86 15137562688

Sponsors and collaborators

Lead sponsor

The First Affiliated Hospital of Soochow University

Other

Registry information

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Apr 27, 2026
Registry last updated
Apr 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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